Boc-Tyr(SO3H)-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Ph-NH2

Base Information

Chemical Name:Boc-Tyr(SO3H)-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Ph-NH2
CAS No.:119038-27-6
Molecular Formula:C₅₃H₇₂N₈O₁₄S
Molecular Weight:1077.27
Hs Code.:

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Chemical Property of Boc-Tyr(SO3H)-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Ph-NH2

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Technology Process of Boc-Tyr(SO3H)-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Ph-NH2

There total 10 articles about Boc-Tyr(SO3H)-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Ph-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 119038-12-9
Boc-Tyr-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Phe-NH2

: 119038-27-6
Boc-Tyr(SO3H)-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Ph-NH2

Guidance literature:: With pyridine-SO₃ complex; In pyridine; N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1016/S0040-4020(01)86144-5

Reference yield:

: 6404-28-0
Boc-Nle-OH

: 119038-27-6
Boc-Tyr(SO3H)-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Ph-NH2

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) N-methylmorpholine, i-butyl-chloroformiate 2.) Ag-benzoate 3.) Ag-benzoate, triethylamine / 1.) ethyleneglycol dimethylether, 5 min, 0 deg C, 2.) ether, 0 deg C, 20 min, 3.) MeOH, 30 min, RT

2: 95 percent / diisopropylethylamine, 4-(N,N-dimethyl)-amino-pyridine, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 0 deg C, then RT, 4h

3: LiAlH₄ / ether, 0 deg C, 30 min

4: benzene / 1 h / Ambient temperature

5: 83 percent / 2 N NaOH / methanol; H₂O / 2 h / 30 °C

6: 73 percent / H₂ / 10percentPd/C / ethyl acetate / 1 h / 3677.5 Torr / Ambient temperature

7: 1.) trifluoroacetic acid 2.) N,N-diisopropylethylamine / 1.) 30 min, RT, 2.) DMF, 2 h, RT

8: 1.) diethylamine 2.) iisopropylethylamine, benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate / 1.) MF, 20 min, RT, 2.) DMF, 4 h, RT

9: 85 percent / H₂ / 10percent Pd/C / dimethylformamide; ethanol / Ambient temperature

10: 50 percent / SO₃-pyridine complex / pyridine; dimethylformamide / Ambient temperature

With 4-methyl-morpholine; dmap; sodium hydroxide; lithium aluminium tetrahydride; pyridine-SO₃ complex; hydrogen; silver benzoate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; 10% palladium on active carbon; In pyridine; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)86144-5

Reference yield:

: 119005-44-6
[(S)-1-(2-Oxo-ethyl)-pentyl]-carbamic acid tert-butyl ester

: 119038-27-6
Boc-Tyr(SO3H)-Nle-Ψ(CH2-CH2)-Gly-Trp-Nle-Asp-Ph-NH2

Guidance literature:: Multi-step reaction with 7 steps

1: benzene / 1 h / Ambient temperature

2: 83 percent / 2 N NaOH / methanol; H₂O / 2 h / 30 °C

3: 73 percent / H₂ / 10percentPd/C / ethyl acetate / 1 h / 3677.5 Torr / Ambient temperature

4: 1.) trifluoroacetic acid 2.) N,N-diisopropylethylamine / 1.) 30 min, RT, 2.) DMF, 2 h, RT

5: 1.) diethylamine 2.) iisopropylethylamine, benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate / 1.) MF, 20 min, RT, 2.) DMF, 4 h, RT

6: 85 percent / H₂ / 10percent Pd/C / dimethylformamide; ethanol / Ambient temperature

7: 50 percent / SO₃-pyridine complex / pyridine; dimethylformamide / Ambient temperature

With sodium hydroxide; pyridine-SO₃ complex; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; 10% palladium on active carbon; In pyridine; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0040-4020(01)86144-5