trans-Cyclopropanecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-

Base Information

• Chemical Name: trans-Cyclopropanecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-
• CAS No.: 1638768-80-5
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.249
• European Community (EC) Number: 844-224-4,961-839-4
• Mol file: 1638768-80-5.mol

Synonyms:952708-48-4;trans-cyclopropanecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-;153861-53-1;(1R,2R)-rel-2-(((tert-Butoxycarbonyl)amino)methyl)cyclopropanecarboxylic acid;(1R,2R)-2-[(tert-Butoxycarbonylamino)methyl]cyclopropanecarboxylic acid;(1R,2R)-2-(((tert-Butoxycarbonyl)amino)methyl)cyclopropanecarboxylic acid;(1R,2R)-2-[[(2-methylpropan-2-yl)oxycarbonylamino]methyl]cyclopropane-1-carboxylic acid;rel-(1R,2R)-2-[[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]cyclopropanecarboxylic acid;trans-2-((Boc-amino)methyl)cyclopropane-1-carboxylic acid;MFCD28501612;(1R,2R)-2-({[(tert-butoxy)carbonyl]amino}methyl)cyclopropane-1-carboxylic acid;1638768-80-5;SCHEMBL4290565;ZVABYODYESELSO-NKWVEPMBSA-N;AMY35658;CNB70848;AKOS025396266;AT35268;AS-52775;CS-0047741;P15608;EN300-1277656;trans-2-[(tert-butoxycarbonylamino)methyl]cyclopropanecarboxylic acid;(+/-)-(1R,2R)-2-((tert-butoxycarbonylamino)methyl)cyclopropanecarboxylic acid;(1R,2R)-2-(((TERT-BUTOXYCARBONYL)AMINO)METHYL)CYCLOPROPANE-1-CARBOXYLIC ACID;rac-(1R,2R)-2-({[(tert-butoxy)carbonyl]amino}methyl)cyclopropane-1-carboxylic acid;rac-(1R,2R)-2-({[(tert-butoxy)carbonyl]amino}methyl)cyclopropane-1-carboxylic acid, trans;trans-2-[[[(1,1-Dimethylethoxy)carbonyl]amino]methyl]cyclopropanecarboxylic acid;trans-cyclopropanecarboxylic acid,2-[[[(1,1-dimethyl ethoxy)carbonyl]amino]methyl]-

Chemical Property of trans-Cyclopropanecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-

Chemical Property:

• XLogP3: 0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 215.11575802
• Heavy Atom Count: 15
• Complexity: 269

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCC1CC1C(=O)O
• Isomeric SMILES: CC(C)(C)OC(=O)NC[C@@H]1C[C@H]1C(=O)O

Technology Process of trans-Cyclopropanecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-

There total 25 articles about trans-Cyclopropanecarboxylic acid, 2-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-tert-butoxycarbonyl[(1S,2S)-2-(aminomethyl)cyclopropyl]methanol (1262755-28-1,167255-48-3,167255-49-4) → (1R,2R)-1-<methyl>-2-carboxycyclopropane (153861-53-1,1638768-80-5)

Guidance literature:

N-tert-butoxycarbonyl[(1S,2S)-2-(aminomethyl)cyclopropyl]methanol; With Dess-Martin periodane; In dichloromethane; at 0 - 20 ℃; for 2h;

With sodium chlorite; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 13h;

DOI:10.1016/j.bmc.2013.06.063

Reference yield: 82.0%

((1R,2R)-2-Hydroxymethyl-cyclopropylmethyl)-carbamic acid tert-butyl ester (167255-48-3,167255-49-4) → (1R,2R)-1-<methyl>-2-carboxycyclopropane (153861-53-1,1638768-80-5)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; at 0 ℃;

DOI:10.1021/jo00080a017

Reference yield: 80.0%

(1S,2S)-1-[[(N-tert-butoxycarbonyl)amino]methyl]-phenylcyclopropane (253779-05-4) → (1S,2S)-1-[[(N-tert-butoxycarbonyl)amino]methyl]-carboxycyclopropane (1638768-80-5)

Guidance literature:

With sodium periodate; ruthenium trichloride; In tetrachloromethane; water; acetonitrile; for 30h;

DOI:10.1080/00397919908085899

upstream raw materials:

((1R,2R)-2-Hydroxymethyl-cyclopropylmethyl)-carbamic acid tert-butyl ester

(1S,2S)-1-[[(N-tert-butoxycarbonyl)amino]methyl]-phenylcyclopropane

(1R,2R)-2-<<(tert-Butyldiphenylsilyl)oxy>methyl>-1-(hydroxymethyl)cyclopropane

(2-(((tert-butyldiphenylsilyl)oxy)methyl)cyclopropyl)methanamine