5-Amino-2-fluorophenol

Base Information

• Chemical Name: 5-Amino-2-fluorophenol
• CAS No.: 100367-48-4
• Molecular Formula: C6H6FNO
• Molecular Weight: 127.118
• Hs Code.: 2922290090
• Mol file: 100367-48-4.mol

Synonyms:Phenol,5-amino-2-fluoro;4-Fluoro-3-hydroxyaniline;aminofluorophenol;

Chemical Property of 5-Amino-2-fluorophenol

Chemical Property:

• Melting Point: 156-158℃
• PSA: 46.25000
• LogP: 1.69470

Purity/Quality:

97%+ ^*data from raw suppliers

5-Amino-2-fluorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Amino-2-fluorophenol is used as synthetic building block.

Technology Process of 5-Amino-2-fluorophenol

There total 2 articles about 5-Amino-2-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-fluoro-5-nitrophenol (22510-08-3) → 2-fluoro-5-aminophenol (100367-48-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 24h;

Reference yield: 73.0%

4-fluoro-3-methoxyaniline (64465-53-8) → 2-fluoro-5-aminophenol (100367-48-4)

Guidance literature:

4-fluoro-3-methoxyaniline; With boron tribromide; In dichloromethane; at 0 - 20 ℃;

With methanol; In dichloromethane;

With sodium hydrogencarbonate; In water; Saturated solution;

Reference yield: 95.0%

2-fluoro-5-aminophenol (100367-48-4) + di-tert-butyl dicarbonate (24424-99-5) → C11H14FNO3 (694514-22-2)

Guidance literature:

In tetrahydrofuran; for 18h; Reflux;

DOI:10.1016/j.bmcl.2009.05.102

upstream raw materials:

4-fluoro-3-methoxyaniline

2-fluoro-5-nitrophenol

Downstream raw materials:

1-(5-tert-butylisoxazol-3-yl)-3-(4-fluoro-3-hydroxyphenyl)urea

C₁₁H₁₄FNO₃

C₁₇H₁₇FN₂O₅S

meta-hydroxycabozantinib

Refernces

• 1、 -. "Diphenyl sulfate derivatives or pharmaceutically acceptable salts thereof, preparation method thereof and pharmaceutical composition for use in preventing or treating hepatitis C virus related diseases". Paragraph 0197-0199. . Retrieved 2017/05/23.
• 2、 -. "TRPV4 ANTAGONISTS". Page/Page column 45. . Retrieved 2011/10/13.