Technology Process of (4S,5S)-(-)-1-Iodo-4-acetoxy-10-methyl-5-(p-toluenesulfonyloxy)undecane
There total 5 articles about (4S,5S)-(-)-1-Iodo-4-acetoxy-10-methyl-5-(p-toluenesulfonyloxy)undecane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
for 12h;
Ambient temperature;
DOI:10.1021/jo00106a030
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) CuI / 1.) Et2O, 2.) -70 deg C, 1 h; -30 deg C, 2 h
2: 91 percent / H2 / 10percent Pd/C / diethyl ether / 4 h / 1520 Torr
3: 90 percent / pyridine / CHCl3 / 18 h / 0 °C
4: 88 percent / Me3SiCl, NaI / acetonitrile / 18 h / Ambient temperature
5: 100 percent / PTSA / 12 h / Ambient temperature
With
pyridine; copper(l) iodide; chloro-trimethyl-silane; hydrogen; toluene-4-sulfonic acid; sodium iodide;
palladium on activated charcoal;
In
diethyl ether; chloroform; acetonitrile;
DOI:10.1021/jo00106a030
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / H2 / 10percent Pd/C / diethyl ether / 4 h / 1520 Torr
2: 90 percent / pyridine / CHCl3 / 18 h / 0 °C
3: 88 percent / Me3SiCl, NaI / acetonitrile / 18 h / Ambient temperature
4: 100 percent / PTSA / 12 h / Ambient temperature
With
pyridine; chloro-trimethyl-silane; hydrogen; toluene-4-sulfonic acid; sodium iodide;
palladium on activated charcoal;
In
diethyl ether; chloroform; acetonitrile;
DOI:10.1021/jo00106a030
