(4aR,9aS,9bR)-4a,6,6,9a-tetramethyl-trans-perhydroindano<2,1-c>pyran

Base Information

• Chemical Name: (4aR,9aS,9bR)-4a,6,6,9a-tetramethyl-trans-perhydroindano<2,1-c>pyran
• CAS No.: 85611-48-9
• Molecular Formula: C₁₆H₂₈O
• Molecular Weight: 236.398
• Mol file: 85611-48-9.mol

Synonyms:

Chemical Property of (4aR,9aS,9bR)-4a,6,6,9a-tetramethyl-trans-perhydroindano<2,1-c>pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aR,9aS,9bR)-4a,6,6,9a-tetramethyl-trans-perhydroindano<2,1-c>pyran

There total 6 articles about (4aR,9aS,9bR)-4a,6,6,9a-tetramethyl-trans-perhydroindano<2,1-c>pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6, 7,8,8a-octahydronaphthalen-1-yl)ethan-1-ol (31207-73-5) → (4aR,9aS,9bR)-4a,6,6,9a-tetramethyl-trans-perhydroindano<2,1-c>pyran (85611-48-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 86 percent / pyridine / 2 h / Ambient temperature

2: 74 percent / monoperphthalic acid / diethyl ether / 3.5 h / Ambient temperature

3: 45 percent / BF₃ etherate / benzene / 2 h / Ambient temperature

4: 94 percent / KMnO₄ / H₂O; acetic acid / 0.42 h / Ambient temperature

5: 91 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

6: 28 percent Turnov_. / p-toluenesulfonic acid / benzene / 3 h / Heating

With pyridine; potassium permanganate; lithium aluminium tetrahydride; monoperoxyphthalic acid; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In diethyl ether; water; acetic acid; benzene;

DOI:10.1007/BF00513253

Reference yield:

(1R,8aS)-Δ2-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-trans-octanhydronaphthalene acetate (61047-05-0) → (4aR,9aS,9bR)-4a,6,6,9a-tetramethyl-trans-perhydroindano<2,1-c>pyran (85611-48-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 74 percent / monoperphthalic acid / diethyl ether / 3.5 h / Ambient temperature

2: 45 percent / BF₃ etherate / benzene / 2 h / Ambient temperature

3: 94 percent / KMnO₄ / H₂O; acetic acid / 0.42 h / Ambient temperature

4: 91 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

5: 28 percent Turnov_. / p-toluenesulfonic acid / benzene / 3 h / Heating

With potassium permanganate; lithium aluminium tetrahydride; monoperoxyphthalic acid; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In diethyl ether; water; acetic acid; benzene;

DOI:10.1007/BF00513253

Reference yield:

(1R,8aS)-2,3-α-epoxy-1-(2-acetoxyethyl)-2,5,5,8a-tetramethyl-trans-decalin (86833-94-5) → (4aR,9aS,9bR)-4a,6,6,9a-tetramethyl-trans-perhydroindano<2,1-c>pyran (85611-48-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 45 percent / BF₃ etherate / benzene / 2 h / Ambient temperature

2: 94 percent / KMnO₄ / H₂O; acetic acid / 0.42 h / Ambient temperature

3: 91 percent / LiAlH₄ / diethyl ether / 4 h / Ambient temperature

4: 28 percent Turnov_. / p-toluenesulfonic acid / benzene / 3 h / Heating

With potassium permanganate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In diethyl ether; water; acetic acid; benzene;

DOI:10.1007/BF00513253

upstream raw materials:

(1R,2R,7aS)-2,4,4,7a-tetramethyl-1-(2-hydroxyethyl)-2-hydroxymethyl-trans-hydrindan

2-((1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6, 7,8,8a-octahydronaphthalen-1-yl)ethan-1-ol

(1R,8aS)-Δ²-1-(2-hydroxyethyl)-2,5,5,8a-tetramethyl-trans-octanhydronaphthalene acetate

(1R,8aS)-2,3-α-epoxy-1-(2-acetoxyethyl)-2,5,5,8a-tetramethyl-trans-decalin