Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester

Base Information

Chemical Name:Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester
CAS No.:1054617-94-5
Molecular Formula:C₆₉H₆₂Cl₈O₁₃P₄
Molecular Weight:1506.76
Hs Code.:

Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester

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Chemical Property of Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester

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Technology Process of Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester

There total 9 articles about Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147514-07-6
Methyl 3-O-benzoyl-2-O-benzyl-4,6-O-benzylidene-α-D-glucopyranoside

: 1054617-94-5
Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester

Guidance literature:: Multi-step reaction with 9 steps

1: 98 percent / 80percent aq. AcOH / 1.75 h / Heating

2: PPh₃, CBr₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) r.t., 16 h

3: pyridine, DMAP / 2 h

4: NaI, Bu₄NI, 4 Angstroem molecular sieves / dimethylsulfoxide / 2 h / 100 °C

5: DBU / dimethylsulfoxide / 2 h

6: 8 percent / AcOH, Hg(CF₃CO₂)2 / acetone; H₂O / 30 h

7: 70 percent / NaBH₄ / dioxane / 1 h / Ambient temperature

8: 86 percent / NaOH / methanol / 1.5 h / Heating

9: 1H-tetrazole / CH₂Cl₂ / 1.) r.t., 20 min, 2.) r.t., 30 min

With pyridine; 1H-tetrazole; dmap; sodium hydroxide; sodium tetrahydroborate; carbon tetrabromide; Hg(II) trifluoroacetate; 4 A molecular sieve; tetra-(n-butyl)ammonium iodide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1039/p19960001365

Reference yield:

: 147425-46-5
methyl 3‐O‐benzoyl‐2‐O‐benzyl‐α‐D-glucopyranoside

: 1054617-94-5
Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester

Guidance literature:: Multi-step reaction with 8 steps

1: PPh₃, CBr₄ / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) r.t., 16 h

2: pyridine, DMAP / 2 h

3: NaI, Bu₄NI, 4 Angstroem molecular sieves / dimethylsulfoxide / 2 h / 100 °C

4: DBU / dimethylsulfoxide / 2 h

5: 8 percent / AcOH, Hg(CF₃CO₂)2 / acetone; H₂O / 30 h

6: 70 percent / NaBH₄ / dioxane / 1 h / Ambient temperature

7: 86 percent / NaOH / methanol / 1.5 h / Heating

8: 1H-tetrazole / CH₂Cl₂ / 1.) r.t., 20 min, 2.) r.t., 30 min

With pyridine; 1H-tetrazole; dmap; sodium hydroxide; sodium tetrahydroborate; carbon tetrabromide; Hg(II) trifluoroacetate; 4 A molecular sieve; tetra-(n-butyl)ammonium iodide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1039/p19960001365

Reference yield:

: 1055037-79-0
Benzoic acid (2S,3R,4S,5S,6S)-3-benzyloxy-6-bromomethyl-5-hydroxy-2-methoxy-tetrahydro-pyran-4-yl ester

: 1054617-94-5
Phosphorous acid (1R,2S,3R,4R,5S)-2-benzyloxy-3,4,5-tris-[bis-(4-chloro-benzyloxy)-phosphanyloxy]-cyclohexyl ester bis-(4-chloro-benzyl) ester

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine, DMAP / 2 h

2: NaI, Bu₄NI, 4 Angstroem molecular sieves / dimethylsulfoxide / 2 h / 100 °C

3: DBU / dimethylsulfoxide / 2 h

4: 8 percent / AcOH, Hg(CF₃CO₂)2 / acetone; H₂O / 30 h

5: 70 percent / NaBH₄ / dioxane / 1 h / Ambient temperature

6: 86 percent / NaOH / methanol / 1.5 h / Heating

7: 1H-tetrazole / CH₂Cl₂ / 1.) r.t., 20 min, 2.) r.t., 30 min

With pyridine; 1H-tetrazole; dmap; sodium hydroxide; sodium tetrahydroborate; Hg(II) trifluoroacetate; 4 A molecular sieve; tetra-(n-butyl)ammonium iodide; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; acetone;
DOI:10.1039/p19960001365