4-Aminomethyl-phenol hydrochloride

Base Information

• Chemical Name: 4-Aminomethyl-phenol hydrochloride
• CAS No.: 1004-23-5
• Molecular Formula: C7H9NO.ClH
• Molecular Weight: 159.615
• Hs Code.: 2922299090
• Mol file: 1004-23-5.mol

Synonyms:p-hydroxybenzylamine hydrochloride;X6145;4-hydroxybenzene-methanamine-hydrochloride;4-AMINOMETHYL-PHENOL HYDROCHLORIDE;4-Hydroxybenzylamine hydrochloride;4-Aminomethyl-phenol,Hydrochlorid;Phenol,4-(aminomethyl)-,hydrochloride;4-hydroxybenzenemethaneamine hydrochloride;

Chemical Property of 4-Aminomethyl-phenol hydrochloride

Chemical Property:

• PSA: 46.25000
• LogP: 2.35320

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Aminomethyl-phenolhydrochloride 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Aminomethyl-phenol hydrochloride

There total 6 articles about 4-Aminomethyl-phenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-cyanophenol (767-00-0) → 4-hydroxy-benzylamine hydrochloride (1004-23-5)

Guidance literature:

With hydrogenchloride; hydrogen; In propan-1-ol; water; at 60 ℃; for 18h; under 1125.11 Torr; Flow reactor;

DOI:10.1002/open.201600166

Reference yield: 65.4%

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-hydroxy-benzylamine hydrochloride (1004-23-5)

Guidance literature:

4-hydroxy-benzaldehyde; With pyridoxal 5'-phosphate; ArRmut₁₁; isopropylamine; for 24h; Enzymatic reaction;

With hydrogenchloride; In diethyl ether; Reagent/catalyst;

DOI:10.1002/adsc.202100997

Reference yield: 62.0%

4-cyanophenol (767-00-0) → 4-hydroxybenzylamine hydrochloride + 4-hydroxy-benzylamine hydrochloride (1004-23-5)

Guidance literature:

4-cyanophenol; With 1,1,3,3-Tetramethyldisiloxane; copper(II) bis(trifluoromethanesulfonate); In 2-methyltetrahydrofuran; at 100 ℃; for 24h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In 2-methyltetrahydrofuran; diethyl ether; at 20 ℃; for 0.0833333h;

DOI:10.1039/c3gc41082j

upstream raw materials:

4-hydroxybenzaldehyde oxime

4-hydroxy-benzaldehyde

4-cyanophenol

Downstream raw materials:

T1-11

C₂₂H₂₆N₆O₅

3,4-dihydroxy-5-[6-(4-hydroxybenzylamino)purin-9-yl]tetrahydrofuran-2-carboxylic acid ethylamide

tert-Butyl N-[{[(tert-butoxy)carbonyl]imino}({[(4-hydroxyphenyl)methyl]amino}) methyl]carbamate

Refernces

• 1、 Saito, Yuki,Ishitani, Haruro,Ueno, Masaharu,Kobayashi, Shū. "Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO2-Supported Palladium Catalyst under Continuous-Flow Conditions". . p. 211 - 215. Retrieved 2017.
• 2、 -. "APPLICATIONS OF N6-SUBSTITUTED ADENOSINE DERIVATIVE AND N6-SUBSTITUTED ADENINE DERIVATIVE TO CALMING, HYPNOSES, CONVULSION RESISTANCE, EPILEPTIC RESISTANCE, PARKINSON DISEASE RESISTANCE, AND DEMENTIA PREVENTION AND TREATMENT". Paragraph 0094. . Retrieved 2018/10/27.