2-butanoyl-3-phenylisomenthopyrazole

Base Information

• Chemical Name: 2-butanoyl-3-phenylisomenthopyrazole
• CAS No.: 524961-80-6
• Molecular Formula: C₂₁H₂₈N₂O
• Molecular Weight: 324.466
• Mol file: 524961-80-6.mol

Synonyms:

Chemical Property of 2-butanoyl-3-phenylisomenthopyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-butanoyl-3-phenylisomenthopyrazole

There total 4 articles about 2-butanoyl-3-phenylisomenthopyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

butyryl chloride (141-75-3) + (4R,7R)-3-phenyl-4-methyl-7-isopropyl-4,5,6,7-tetrahydroindazole (524961-77-1) → 2-butanoyl-3-phenylisomenthopyrazole (524961-80-6) + 1-butanoyl-3-phenylisomenthopyrazole

Guidance literature:

With triethylamine; In toluene;

DOI:10.3987/COM-02-S26

Reference yield:

(+)-(1S,2R,5R)-isomenthol (23283-97-8) → 2-butanoyl-3-phenylisomenthopyrazole (524961-80-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 7.2 g / sodium dichromate dihydrate; aq. sulfuric acid / diethyl ether / 2 h / 20 °C

2.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.25 h / -5 °C

2.2: 38 percent / tetrahydrofuran / 1.5 h / -5 - 20 °C

3.1: 89 percent / hydrazine monohydrate; hydrazine hydrochloride / methanol / 6 h / Heating

4.1: 76 percent / triethylamine / toluene

With n-butyllithium; sodium dichromate; hydrazine hydrochloride; sulfuric acid; hydrazine hydrate; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; toluene;

DOI:10.3987/COM-02-S26

Reference yield:

(1R,4R)-(+)-isomenthone (1196-31-2,17627-49-5,7786-64-3) → 2-butanoyl-3-phenylisomenthopyrazole (524961-80-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diisopropylamine; butyllithium / tetrahydrofuran; hexane / 0.25 h / -5 °C

1.2: 38 percent / tetrahydrofuran / 1.5 h / -5 - 20 °C

2.1: 89 percent / hydrazine monohydrate; hydrazine hydrochloride / methanol / 6 h / Heating

3.1: 76 percent / triethylamine / toluene

With n-butyllithium; hydrazine hydrochloride; hydrazine hydrate; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; hexane; toluene;

DOI:10.3987/COM-02-S26

upstream raw materials:

butyryl chloride

(4R,7R)-3-phenyl-4-methyl-7-isopropyl-4,5,6,7-tetrahydroindazole

(+)-(1S,2R,5R)-isomenthol

(1R,4R)-(+)-isomenthone