(2R,3'S,5R,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylic acid

Base Information

Chemical Name:(2R,3'S,5R,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylic acid
CAS No.:111761-72-9
Molecular Formula:C₁₇H₁₇N₃O₅S
Molecular Weight:375.405
Hs Code.:

(2R,3'S,5R,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro<imidazolidine-2,6'-penam>-3'-carboxylic acid

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Chemical Property of (2R,3'S,5R,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylic acid

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Technology Process of (2R,3'S,5R,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylic acid

There total 14 articles about (2R,3'S,5R,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 111761-71-8,111821-15-9
(2R,3'S,5R,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

: 111761-72-9,111821-88-6
(2R,3'S,5R,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; Ambient temperature;
DOI:10.1039/P19870000635

Reference yield: 59.0%

: 111761-71-8,111821-15-9
(2R,3'S,5S,5'R)-benzyl 1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylate

: 111761-72-9,111821-88-6
(2R,3'S,5S,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; Ambient temperature;
DOI:10.1039/P19870000635

Reference yield:

: 40514-98-5
(6S)-benzyl 6-amino-6-(methylthio)penicillanate

: 111761-72-9,111821-88-6
(2R,3'S,5R,5'R)-1-formyl-2',2'-dimethyl-4-oxo-5-phenylspiro-3'-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / triethylamine / tetrahydrofuran / 0.5 h / Ambient temperature

2: 56 percent / NH₄Cl, Zn powder / tetrahydrofuran; methanol / 0.5 h / Ambient temperature

3: 30 percent / mercuric acetate / tetrahydrofuran / 0.25 h / 0 - 5 °C

4: 76 percent / pyridine / CH₂Cl₂ / 45 min, RT, 1 h, RT

5: 96 percent / H₂ / 10 percent Pd-C / tetrahydrofuran / Ambient temperature

With pyridine; mercury(II) diacetate; hydrogen; ammonium chloride; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1039/P19870000635