2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester
CAS No.:1026174-62-8
Molecular Formula:C₃₇H₅₀N₂O₇Si
Molecular Weight:662.899
Hs Code.:

2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester

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Chemical Property of 2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester

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Technology Process of 2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester

There total 8 articles about 2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142841-00-7
2-[bromomethyl]-4-oxazolecarboxylic acid ethyl ester

: 155089-04-6
[(2E,4E)-(S)-6-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-8-oxo-octa-2,4-dienyl]-carbamic acid tert-butyl ester

: 1026174-62-8
2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester

Guidance literature:: With zinc; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(00)60128-4

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1026174-62-8
2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 25 °C

2: 87 percent / i-Bu₂AlH / tetrahydrofuran / -78 °C

3: activated Zn / tetrahydrofuran / 0 °C

With 1H-imidazole; diisobutylaluminium hydride; zinc; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)60128-4

Reference yield:

: ((2E,4E)-6-Hydroxy-4-methyl-hexa-2,4-dienyl)-carbamic acid tert-butyl ester

: 1026174-62-8
2-[(5E,7E)-(S)-9-tert-Butoxycarbonylamino-4-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-6-methyl-nona-5,7-dienyl]-oxazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: DMSO, (COCl)2, NEt₃ / CH₂Cl₂ / -78 °C

2: LDA / tetrahydrofuran / -78 °C

3: AlMe₃ / tetrahydrofuran / 0 °C

4: imidazole / dimethylformamide / 25 °C

5: 87 percent / i-Bu₂AlH / tetrahydrofuran / -78 °C

6: activated Zn / tetrahydrofuran / 0 °C

With 1H-imidazole; oxalyl dichloride; trimethylaluminum; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; zinc; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)60128-4