tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[3-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Base Information

Chemical Name:tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[3-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate
CAS No.:918309-15-6
Molecular Formula:C₃₀H₃₂N₄O₅S
Molecular Weight:560.674
Hs Code.:

tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[3-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

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Chemical Property of tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[3-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

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Technology Process of tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[3-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

There total 1 articles about tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[3-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 881997-05-3
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

: 87199-15-3
[3-(hydroxymethyl)phenyl]boronic acid

: 918309-15-6
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[3-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 23h; Heating;
DOI:10.1016/j.bmc.2006.08.037

Reference yield:

: 918309-15-6
tert-butyl (2E)-3-(8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-2-[3-(hydroxymethyl)phenyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

: 918309-30-5
tert-butyl (2E)-3-(2-[3-(bromomethyl)phenyl]-8-{[(4-tert-butyl-1,3-thiazol-2-yl)amino]carbonyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-3-yl)acrylate

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmc.2006.08.037