(1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol

Base Information

Chemical Name:(1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol
CAS No.:1026711-95-4
Molecular Formula:C₄₂H₈₀O₄Si₃
Molecular Weight:733.351
Hs Code.:

(1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol

Synonyms:

Suppliers and Price of (1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol

There total 6 articles about (1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171011-37-3
4-bromo-2-(hydroxymethyl)benzyl alcohol

: 1026711-95-4
(1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 37 percent / 4-(dimethylamino)pyridine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

2: 85 percent / PCC, Celite / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 87 percent / tetrahydrofuran; cyclohexane; diethyl ether / -78 - 20 °C

4: 1.) 9-BBN, 2.) 6 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, from 0 deg C to RT, 4 h, 2.) THF, ethanol, 50 deg C, 1 h

5: 96 percent / 4-(dimethylamino)pyridine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

6: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 30 min, 2.) THF, pentane, -78 deg C, 2 h

With dmap; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; Celite; dihydrogen peroxide; tert.-butyl lithium; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00022a019

Reference yield:

: 87639-57-4
4-bromophthalic Acid Dimethyl Ester

: 1026711-95-4
(1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / LiAlH₄ / tetrahydrofuran; diethyl ether / a) RT, 1 h, b) reflux, 1.5 h

2: 37 percent / 4-(dimethylamino)pyridine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

3: 85 percent / PCC, Celite / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 87 percent / tetrahydrofuran; cyclohexane; diethyl ether / -78 - 20 °C

5: 1.) 9-BBN, 2.) 6 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, from 0 deg C to RT, 4 h, 2.) THF, ethanol, 50 deg C, 1 h

6: 96 percent / 4-(dimethylamino)pyridine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

7: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 30 min, 2.) THF, pentane, -78 deg C, 2 h

With dmap; sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; Celite; dihydrogen peroxide; tert.-butyl lithium; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00022a019

Reference yield:

: 1026266-91-0
5-Bromo-2-(tert-butyl-dimethyl-silanyloxymethyl)-benzaldehyde

: 1026711-95-4
(1R,3aR,7aR)-4-[3-[2-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-((R)-1,5-dimethyl-5-trimethylsilanyloxy-hexyl)-7a-methyl-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / tetrahydrofuran; cyclohexane; diethyl ether / -78 - 20 °C

2: 1.) 9-BBN, 2.) 6 N aq. NaOH, 30percent aq. H₂O₂ / 1.) THF, from 0 deg C to RT, 4 h, 2.) THF, ethanol, 50 deg C, 1 h

3: 96 percent / 4-(dimethylamino)pyridine / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

4: 1.) t-BuLi / 1.) THF, pentane, -78 deg C, 30 min, 2.) THF, pentane, -78 deg C, 2 h

With dmap; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00022a019