C₁₈H₂₀FN₅O₅

Base Information

• Chemical Name: C₁₈H₂₀FN₅O₅
• CAS No.: 1193687-86-3
• Molecular Formula: C₁₈H₂₀FN₅O₅
• Molecular Weight: 405.386
• Mol file: 1193687-86-3.mol

Synonyms:

Chemical Property of C₁₈H₂₀FN₅O₅

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

N1-[1-[4-[[[(4-Fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]ethanediamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N1-[1-[4-[[[(4-Fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]ethanediamide, is an impurity of Raltegravir Potassium (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.

Technology Process of C₁₈H₂₀FN₅O₅

There total 2 articles about C₁₈H₂₀FN₅O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (2-(4-(4-fluorobenzylcarbamoyl)-1,6-dihydro-5-hydroxy-1-methyl-6-oxopyrimidin-2-yl)propan-2-ylcarbamoyl)formate (1193687-88-5) → C18H20FN5O5 (1193687-86-3)

Guidance literature:

With ammonia; In methanol; under 1500.15 - 2250.23 Torr; Autoclave;

DOI:10.1021/op300077m

Reference yield:

C17H20FN3O3 → C18H20FN5O5 (1193687-86-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

2: ammonia / methanol / 1500.15 - 2250.23 Torr / Autoclave

With ammonia; triethylamine; In methanol; dichloromethane;

DOI:10.1021/op300077m

upstream raw materials:

ethyl (2-(4-(4-fluorobenzylcarbamoyl)-1,6-dihydro-5-hydroxy-1-methyl-6-oxopyrimidin-2-yl)propan-2-ylcarbamoyl)formate