PNN

Base Information

• Chemical Name: PNN
• CAS No.: 863971-66-8
• Molecular Formula: C₁₉H₃₅N₂P
• Molecular Weight: 322.474
• Mol file: 863971-66-8.mol

Synonyms:

Chemical Property of PNN

Chemical Property:

• Refractive Index: n20/D1.519
• Boiling Point: 130 °C(Press: 0.02 Torr)
• PKA: 8.65±0.25(Predicted)
• Flash Point: 67℃
• Density: 0.936 g/mL at 25 °C
• Sensitive.: air sensitive

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Di-t-butylphosphinomethyl)-6-(diethylaminomethyl)pyridine, 98% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xi
• Statements: 15-36/37/38
• Safety Statements: 26-36/37-43

MSDS Files:

Useful:

Technology Process of PNN

There total 3 articles about PNN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-ethyl-N-((6-methylpyridin-2-yl)methyl)ethanamine (863971-65-7) + di(tert-butyl)chlorophosphine (13716-10-4) → [(2-(di-tert-butylphosphinomethyl)-6-diethylaminomethyl)pyridine] (863971-66-8)

Guidance literature:

N-ethyl-N-((6-methylpyridin-2-yl)methyl)ethanamine; With n-butyllithium; In diethyl ether; hexane; at 0 ℃; for 2h;

di(tert-butyl)chlorophosphine; In diethyl ether; hexane; at -78 - 20 ℃;

DOI:10.1021/ja052862b

Reference yield:

2,6-dimethylpyridine (108-48-5) → [(2-(di-tert-butylphosphinomethyl)-6-diethylaminomethyl)pyridine] (863971-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NBS; 2,2'-azobisisobutyrlnitrile / CCl₄ / 7 h

2.1: 17.5 g / tetrahydrofuran / 0 - 20 °C

3.1: n-BuLi / diethyl ether; hexane / 2 h / 0 °C

3.2: 70 percent / diethyl ether; hexane / -78 - 20 °C

With N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); In tetrahydrofuran; tetrachloromethane; diethyl ether; hexane;

DOI:10.1021/ja052862b

Reference yield:

2-(bromomethyl)-6-methylpyridine (68470-59-7) → [(2-(di-tert-butylphosphinomethyl)-6-diethylaminomethyl)pyridine] (863971-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 17.5 g / tetrahydrofuran / 0 - 20 °C

2.1: n-BuLi / diethyl ether; hexane / 2 h / 0 °C

2.2: 70 percent / diethyl ether; hexane / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;

DOI:10.1021/ja052862b

upstream raw materials:

N-ethyl-N-((6-methylpyridin-2-yl)methyl)ethanamine

di(tert-butyl)chlorophosphine

2,6-dimethylpyridine

2-(bromomethyl)-6-methylpyridine

Downstream raw materials:

[Rh(2-(CH₂-PtBu₂)-6-(CH₂-NEt₂)C₅H₃N)(NH₂C₆H₅)]BF₄

[Rh(2-(CH₂-PtBu₂)-6-(CH₂-NEt₂)C₅H₂N)(p-NO₂-NHC₆H₄)]K

[Rh(2-(CH₂-PtBu₂)-6-(CH₂-NEt₂)C₅H₃N)(p-NO₂-NHC₆H₄)]

[Rh(2-(CH₂-PtBu₂)-6-(CH₂-NEt₂)C₅H₃N)(o-Br-NHC₆H₄)]

Refernces