3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane

Base Information

• Chemical Name: 3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane
• CAS No.: 918957-06-9
• Molecular Formula: C₁₈H₂₁F₅N₂O₅
• Molecular Weight: 440.367
• Mol file: 918957-06-9.mol

Synonyms:

Chemical Property of 3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane

There total 2 articles about 3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Boc-2-(3-benzyloxycarbonylamino-propyl)-[1,3]oxazinane (918957-05-8) → 3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane (918957-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / 4.5 h / 760 Torr

2: 2.35 g / CH₂Cl₂ / 12 h

With hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1002/chem.200600138

Reference yield:

2-(2-amino-ethyl)-[1,3]oxazinane-3-carboxylic acid tert-butyl ester + bis(pentafluorophenyl)carbonate (59483-84-0) → 3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane (918957-06-9)

Guidance literature:

In dichloromethane; for 12h;

DOI:10.1002/chem.200600138

Reference yield:

3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane (918957-06-9) + C23H24N5O5Pol → ApaBB(Im-GlyBB)-PheOH

Guidance literature:

3-Boc-2-(1-pentafluorophenyloxycarbonylamino-propyl)-[1,3]oxazinane; C₂₃H₂₄N₅O₅Pol; In N,N-dimethyl-formamide; for 12h; solid phase reaction;

With water; sodium hydroxide; for 2h; solid phase reaction;

DOI:10.1002/chem.200900633

upstream raw materials:

bis(pentafluorophenyl)carbonate

3-Boc-2-(3-benzyloxycarbonylamino-propyl)-[1,3]oxazinane