Cyclo(-(Lys(Z))2-Gly-(Phe)2-(Sar)3-)

Base Information

Chemical Name:Cyclo(-(Lys(Z))2-Gly-(Phe)2-(Sar)3-)
CAS No.:127862-91-3
Molecular Formula:C₅₇H₇₂N₁₀O₁₂
Molecular Weight:1089.26
Hs Code.:

Synonyms:

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Chemical Property of Cyclo(-(Lys(Z))2-Gly-(Phe)2-(Sar)3-)

Chemical Property:

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Technology Process of Cyclo(-(Lys(Z))2-Gly-(Phe)2-(Sar)3-)

There total 4 articles about Cyclo(-(Lys(Z))2-Gly-(Phe)2-(Sar)3-) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 127862-97-9
H-(Lys(Z))2-Gly-(Phe)2-(Sar)3-OH*TFA

: 127862-91-3
Cyclo(-(Lys(Z))2-Gly-(Phe)2-(Sar)3-)

Guidance literature:: With 4-methyl-morpholine; potassium chloride; cesium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium chloride; sodium chloride; In tetrahydrofuran; N,N-dimethyl-formamide; for 240h; Ambient temperature;
DOI:10.1248/cpb.40.570

Reference yield:

: 127862-95-7
Boc-(Lys(Z))2-Gly-(Phe)2-(Sar)3-OMe

: 127862-91-3
Cyclo(-(Lys(Z))2-Gly-(Phe)2-(Sar)3-)

Guidance literature:: Multi-step reaction with 3 steps

1: 1 N NaOH / methanol / 40 °C

2: TFA-anisole

3: 41 percent / N-methylmorpholine, HOBt, EDCI*HCl, LiCl, NaCl, KCl, CsCl / dimethylformamide; tetrahydrofuran / 240 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; TFA-anisole; potassium chloride; cesium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium chloride; sodium chloride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.3166

Reference yield:

: 141540-54-7
Boc-(Lys(Z))2-Gly-(Phe)2-(Sar)3-OH

: 127862-91-3
Cyclo(-(Lys(Z))2-Gly-(Phe)2-(Sar)3-)

Guidance literature:: Multi-step reaction with 2 steps

1: TFA-anisole

2: 41 percent / N-methylmorpholine, HOBt, EDCI*HCl, LiCl, NaCl, KCl, CsCl / dimethylformamide; tetrahydrofuran / 240 h / Ambient temperature

With 4-methyl-morpholine; TFA-anisole; potassium chloride; cesium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium chloride; sodium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.37.3166