Technology Process of 5,8,10-Heptadecatrienoic acid, 12-hydroxy-, (E,E,Z)-
There total 9 articles about 5,8,10-Heptadecatrienoic acid, 12-hydroxy-, (E,E,Z)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1H-imidazole
2: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
3: tetrabutyl ammonium fluoride
4: triethylamine; dmap / dichloromethane
5: sodium iodide / acetone
6: acetonitrile
7: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C
8: tetrabutyl ammonium fluoride
9: lithium hydroxide / tetrahydrofuran; water
With
1H-imidazole; dmap; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; triethylamine; sodium iodide; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;
2: |Suzuki-Miyaura Coupling / 7: |Wittig Olefination;
DOI:10.1055/s-0033-1338961
- Guidance literature:
-
Multi-step reaction with 8 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium hydroxide / tetrahydrofuran; water / 3 h / 20 °C
2: tetrabutyl ammonium fluoride
3: triethylamine; dmap / dichloromethane
4: sodium iodide / acetone
5: acetonitrile
6: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C
7: tetrabutyl ammonium fluoride
8: lithium hydroxide / tetrahydrofuran; water
With
dmap; tetrakis(triphenylphosphine) palladium(0); tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; triethylamine; sodium iodide; sodium hydroxide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;
1: |Suzuki-Miyaura Coupling / 6: |Wittig Olefination;
DOI:10.1055/s-0033-1338961
- Guidance literature:
-
Multi-step reaction with 7 steps
1: tetrabutyl ammonium fluoride
2: triethylamine; dmap / dichloromethane
3: sodium iodide / acetone
4: acetonitrile
5: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C
6: tetrabutyl ammonium fluoride
7: lithium hydroxide / tetrahydrofuran; water
With
dmap; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; triethylamine; sodium iodide; lithium hydroxide;
In
tetrahydrofuran; dichloromethane; water; acetone; acetonitrile;
5: |Wittig Olefination;
DOI:10.1055/s-0033-1338961