2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester

Base Information

Chemical Name:2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester
CAS No.:860476-71-7
Molecular Formula:C₅₁H₇₂N₂O₁₆
Molecular Weight:969.136
Hs Code.:

2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester

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Chemical Property of 2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester

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Technology Process of 2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester

There total 1 articles about 2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 860476-70-6
carbonic acid benzyl ester 4-(benzyloxycarbonyl-methyl-amino)-2-(14-ethyl-12,13-dihydroxy-10-hydroxyimino-7-methoxy-3,5,7,9,11,13-hexamethyl-2,4-dioxo-oxacyclotetradec-6-yloxy)-6-methyl-tetrahydro-pyran-3-yl ester

: 205114-95-0
(S)-2-bromo-propionic acid allyl ester

: 860476-71-7
2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 0.5h; cooling;
DOI:10.1016/j.bmc.2006.01.036

Reference yield:

: 860476-71-7
2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester

: 860476-78-4
C₆₀H₇₇N₅O₁₆

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 20 °C

2.1: PPh₃; pyrrolidine; H₂O / Pd(PPh₃)4 / acetonitrile; ethyl acetate / 1 h / 20 °C

3.1: oxalyl chloride; DMF / toluene / 1.5 h / 20 °C

3.2: toluene; tetrahydrofuran / 0.25 h

With pyrrolidine; pyridine; oxalyl dichloride; water; N,N-dimethyl-formamide; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile;
DOI:10.1016/j.bmc.2006.01.036

Reference yield:

: 860476-71-7
2-{10-[4-(benzyloxycarbonyl-methyl-amino)-3-benzyloxycarbonyloxy-6-methyl-tetrahydro-pyran-2-yloxy]-2-ethyl-3,4-dihydroxy-9-methoxy-3,5,7,9,11,13-hexamethyl-12,14-dioxo-oxacyclotetradec-6-ylideneaminooxy}-propionic acid allyl ester

: 892860-40-1
C₆₁H₇₈N₄O₁₆

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 20 °C

2.1: PPh₃; pyrrolidine; H₂O / Pd(PPh₃)4 / acetonitrile; ethyl acetate / 1 h / 20 °C

3.1: oxalyl chloride; DMF / toluene / 1.5 h / 20 °C

3.2: toluene; tetrahydrofuran / 0.25 h

With pyrrolidine; pyridine; oxalyl dichloride; water; N,N-dimethyl-formamide; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethyl acetate; toluene; acetonitrile;
DOI:10.1016/j.bmc.2006.01.036