4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one

Base Information

Chemical Name:4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one
CAS No.:155435-05-5
Molecular Formula:C₄₃H₅₁N₃O₁₅
Molecular Weight:849.889
Hs Code.:

4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one

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Chemical Property of 4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one

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Technology Process of 4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one

There total 14 articles about 4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72423-56-4
3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-methyl-pyrrole-2-carboxylic acid

: 155435-05-5
4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: Multi-step reaction with 10 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 0.5 h / Ambient temperature

2: N,N-dimethylaniline / CH₂Cl₂ / 1.) room temperature, 30 min, 2.) reflux, 15 min

3: sulfuryl chloride / CH₂Cl₂ / 0.25 h

4: AcONa / 1 h / 75 °C

5: 85.5 percent / p-TsOH / CH₂Cl₂ / 2 h

6: 86 percent / stannic chloride / CH₂Cl₂ / 1.5 h / 0 °C

7: 83 percent / NaHCO₃, I, KI / CH₂Cl₂; H₂O / 0.33 h

8: 1.) stannic chloride, 2.) p-TsOH*H₂O, AgOAc / 1.) CH₂Cl₂, 20 min, 2.) THF, 10 h

9: AcOH, Zn / 0.33 h

10: trifluoroacetic acid / 7 h / Ambient temperature

With sulfuryl dichloride; oxalyl dichloride; silver(I) acetate; sodium acetate; tin(IV) chloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; N,N-dimethyl-aniline; N,N-dimethyl-formamide; trifluoroacetic acid; potassium iodide; zinc; In dichloromethane; water;

Reference yield:

: 75975-52-9
3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester

: 155435-05-5
4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 85.5 percent / p-TsOH / CH₂Cl₂ / 2 h

2: 86 percent / stannic chloride / CH₂Cl₂ / 1.5 h / 0 °C

3: 83 percent / NaHCO₃, I, KI / CH₂Cl₂; H₂O / 0.33 h

4: 1.) stannic chloride, 2.) p-TsOH*H₂O, AgOAc / 1.) CH₂Cl₂, 20 min, 2.) THF, 10 h

5: AcOH, Zn / 0.33 h

6: trifluoroacetic acid / 7 h / Ambient temperature

With silver(I) acetate; tin(IV) chloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; potassium iodide; zinc; In dichloromethane; water;

Reference yield:

: 70988-61-3
tert-Butyl 5-methyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrole-2-carboxylate

: 155435-05-5
4-[5-benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,8-bis(2-methoxycarbonylethyl)-3,7-bis(methoxycarbonylmethyl)-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: Multi-step reaction with 9 steps

1: tert-butyl hypochlorite / tetrahydrofuran / 3 h / Ambient temperature

2: aq. Na₂CO₃ / diethyl ether / Heating

4: 85.5 percent / p-TsOH / CH₂Cl₂ / 2 h

5: 86 percent / stannic chloride / CH₂Cl₂ / 1.5 h / 0 °C

6: 83 percent / NaHCO₃, I, KI / CH₂Cl₂; H₂O / 0.33 h

7: 1.) stannic chloride, 2.) p-TsOH*H₂O, AgOAc / 1.) CH₂Cl₂, 20 min, 2.) THF, 10 h

8: AcOH, Zn / 0.33 h

9: trifluoroacetic acid / 7 h / Ambient temperature

With tert-butylhypochlorite; silver(I) acetate; tin(IV) chloride; sodium hydrogencarbonate; sodium carbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; potassium iodide; zinc; In tetrahydrofuran; diethyl ether; dichloromethane; water;