(E)-3-(4-BROMOPHENYL)-2-CYANO-2-PROPENAMIDE

Base Information

• Chemical Name: (E)-3-(4-BROMOPHENYL)-2-CYANO-2-PROPENAMIDE
• CAS No.: 104127-29-9
• Molecular Formula: C₁₀H₇BrN₂O
• Molecular Weight: 251.082
• Mol file: 104127-29-9.mol

Synonyms:

Chemical Property of (E)-3-(4-BROMOPHENYL)-2-CYANO-2-PROPENAMIDE

Chemical Property:

Purity/Quality:

(E)-3-(4-BROMOPHENYL)-2-CYANO-2-PROPENAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

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Technology Process of (E)-3-(4-BROMOPHENYL)-2-CYANO-2-PROPENAMIDE

There total 12 articles about (E)-3-(4-BROMOPHENYL)-2-CYANO-2-PROPENAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-bromo-benzaldehyde (1122-91-4) + cyanoacetic acid amide (107-91-5) → (E)-2-cyano-3-(4-bromophenyl)-2-propenamide (104127-29-9)

Guidance literature:

With 1-methyl-piperazine; In methanol; at 20 ℃; for 20h;

DOI:10.1016/j.bmc.2011.10.061

Reference yield: 89.0%

4-bromo-benzaldehyde (1122-91-4) + malononitrile (109-77-3) → (E)-2-cyano-3-(4-bromophenyl)-2-propenamide (104127-29-9)

Guidance literature:

With trifluorormethanesulfonic acid; In 1,2-dichloro-ethane; at 110 ℃; for 24h; stereoselective reaction;

DOI:10.1039/c7nj05169g

Reference yield: 88.0%

4-bromo-benzaldehyde (1122-91-4) + cyanoacetic acid amide (107-91-5) → 2-cyano-3-(4-bromophenyl)acrylamide (101085-21-6,104127-29-9)

Guidance literature:

With bismuth(lll) trifluoromethanesulfonate; In neat (no solvent); at 80 ℃; for 5.5h; Green chemistry;

DOI:10.13005/ojc/360507

upstream raw materials:

4-bromo-benzaldehyde

cyanoacetic acid amide

5-amino-3-(4-bromophenyl)-2,3-dihydroisoxazole-4-carbonitrile

4-bromobenzylidenemalononitrile

Downstream raw materials:

C₁₈H₁₃N₅O

2-hydroxy-4-(4-bromophenyl)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinolin-3-carbonitrile

3,8-diamino-4,10-di(4-bromophenyl)-4,10-dihydrochromeno[6,5-f]chromene-2,9-dicarbonitrile

3-amino-9-hydroxy-1-(4-bromophenyl)-1H-benzo[f]chromen-2-carbonitrile

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