1-propylazetidin-3-ol

Base Information

• Chemical Name: 1-propylazetidin-3-ol
• CAS No.: 1340301-52-1
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.175
• Mol file: 1340301-52-1.mol

Synonyms:

Chemical Property of 1-propylazetidin-3-ol

Chemical Property:

• Boiling Point: 163.3±33.0 °C(Predicted)
• Density: 1.018±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

1-propylazetidin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-propylazetidin-3-ol

There total 1 articles about 1-propylazetidin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.1%

1-propionylazetidin-3-one → 1-propylazetidin-3-ol (1340301-52-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 75 ℃; for 16h; Cooling with ice;

Reference yield:

1-propylazetidin-3-ol (1340301-52-1) → 3-(2-chlorophenyl)-4-methyl-2-(4-((1-propylazetidin-3-yl)oxy)phenyl)-2H-chromen-7-ol

Guidance literature:

Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

1.2: 0 °C

2.1: sodium hydrogencarbonate / water / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere

4.2: 1.5 h / 0 - 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

With n-butyllithium; tetrabutyl ammonium fluoride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; water;

Reference yield:

1-propylazetidin-3-ol (1340301-52-1) → 2-(3-fluoro-4-((1-propylazetidin-3-yl)oxy)phenyl)-3-(4-hydroxyphenyl)-4-methyl-2H-chromen-7-ol

Guidance literature:

Multi-step reaction with 4 steps

1: 1,10-Phenanthroline; caesium carbonate; copper(l) iodide / 40 h / 120 °C

2: piperidine; 1,8-diazabicyclo[5.4.0]undec-7-ene / iso-butanol / 12.33 h / 120 - 130 °C / Dean-Stark

3: tetrahydrofuran / 13 h / 0 - 20 °C

4: acetic acid / water / 1 h / 90 °C / Inert atmosphere

With piperidine; copper(l) iodide; 1,10-Phenanthroline; caesium carbonate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; water; iso-butanol; 1: |Ullmann Condensation;

Refernces

• 1、 -. "REGIMENS OF ESTROGEN RECEPTOR ANTAGONISTS". Paragraph 0087; 0090-0091. . Retrieved 2021/01/29.
• 2、 -. "ANTI-ESTROGENIC COMPOUNDS". Paragraph 0140-0142. . Retrieved 2016/11/14.