Phenylephrine EP Impurity D

Base Information

Chemical Name:Phenylephrine EP Impurity D
CAS No.:1367567-95-0
Molecular Formula:C₁₆H₁₉NO₂
Molecular Weight:257.332
Hs Code.:2922504500
Mol file:1367567-95-0.mol

Synonyms:

Suppliers and Price of Phenylephrine EP Impurity D

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(αR)-3-Hydroxy-α-[[methyl(phenylmethyl)amino]methyl]-benzenemethanol
10mg
$ 185.00

Medical Isotopes, Inc.
(αR)-3-Hydroxy-α-[[methyl(phenylmethyl)amino]methyl]-benzenemethanol
100 mg
$ 2200.00

Total 10 raw suppliers

Chemical Property of Phenylephrine EP Impurity D

Chemical Property:

Melting Point:108 - 113°C
Boiling Point:437.5±40.0 °C(Predicted)
PKA:9.76±0.10(Predicted)
Density:1.170±0.06 g/cm3(Predicted)
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

(αR)-3-Hydroxy-α-[[methyl(phenylmethyl)amino]methyl]-benzenemethanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (αR)-3-Hydroxy-α-[[methyl(phenylmethyl)amino]methyl]-benzenemethanol (Phenylephrine USP Related Compound D) is a derivative of (R)-Phenylephrine (P320640, HCl salt) which is an α-Adrenergic agonist.

Technology Process of Phenylephrine EP Impurity D

There total 5 articles about Phenylephrine EP Impurity D which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: N-benzyl-N-methyl-2-amino-m-hydroxyacetophenone

: 1367567-95-0
(R)-3-(2-(benzyl(methyl)amino)-1-hydroxyethyl)phenol

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; C₃₂H₃₉BrMnN₂O₂P; potassium tert-butylate; hydrogen; In methanol; at 20 ℃; for 16h; under 22502.3 Torr; enantioselective reaction; Glovebox; Autoclave;
DOI:10.1002/anie.201814751

Reference yield:

: 71786-67-9
2-(benzyl(methyl)amino)-1-(3'-hydroxyphenyl)ethanone hydrochloride

: 1159977-09-9,1367567-95-0
2-(benzyl(methyl)amino)-1-(3'-hydroxyphenyl)ethanol

Guidance literature:: With bis(1,5-cyclooctadiene)diiridium(I) dichloride; potassium tert-butylate; hydrogen; In isopropyl alcohol; at 20 ℃; for 12h; Temperature; Inert atmosphere; Autoclave;

Reference yield:

: N-benzyl-N-methyl-2-amino-m-hydroxyacetophenone

: 286426-31-1,1367567-95-0
C₁₆H₁₉NO₂

Guidance literature:: With RuCl₂[(S)-xylyl-2,2,6,6’-tetramethoxy-4,4’-bis(diphenylphosphino)-3,3-bipyridine][(R)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]; hydrogen; potassium hydroxide; In water; isopropyl alcohol; at 65 ℃; for 3.5h; under 21002.1 Torr; optical yield given as %ee; enantioselective reaction;
DOI:10.1016/j.tetasy.2010.09.013