(R)-2-[2-{5-[1-((R)-1-Methoxycarbonyl-2-methyl-allyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yldisulfanyl]-[1,3,4]thiadiazol-2-yldisulfanyl}-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid methyl ester

Base Information

• Chemical Name: (R)-2-[2-{5-[1-((R)-1-Methoxycarbonyl-2-methyl-allyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yldisulfanyl]-[1,3,4]thiadiazol-2-yldisulfanyl}-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid methyl ester
• CAS No.: 104574-03-0
• Molecular Formula: C₃₆H₃₈N₆O₁₀S₅
• Molecular Weight: 875.062
• Mol file: 104574-03-0.mol

Synonyms:

Chemical Property of (R)-2-[2-{5-[1-((R)-1-Methoxycarbonyl-2-methyl-allyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yldisulfanyl]-[1,3,4]thiadiazol-2-yldisulfanyl}-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[2-{5-[1-((R)-1-Methoxycarbonyl-2-methyl-allyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yldisulfanyl]-[1,3,4]thiadiazol-2-yldisulfanyl}-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid methyl ester

There total 1 articles about (R)-2-[2-{5-[1-((R)-1-Methoxycarbonyl-2-methyl-allyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yldisulfanyl]-[1,3,4]thiadiazol-2-yldisulfanyl}-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(S)-3,3-Dimethyl-4,7-dioxo-6-(2-phenoxy-acetylamino)-4λ4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester (10209-03-7,24652-74-2,25547-92-6,35345-06-3,57794-62-4) + 2,5-Dimercapto-1,3,4-thiadiazole (1072-71-5,132120-63-9) → (R)-2-[2-{5-[1-((R)-1-Methoxycarbonyl-2-methyl-allyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yldisulfanyl]-[1,3,4]thiadiazol-2-yldisulfanyl}-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid methyl ester (104574-03-0)

Guidance literature:

In 1,4-dioxane; for 7h; Heating;

DOI:10.1016/S0040-4039(01)80900-X

Reference yield:

(R)-2-[2-{5-[1-((R)-1-Methoxycarbonyl-2-methyl-allyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yldisulfanyl]-[1,3,4]thiadiazol-2-yldisulfanyl}-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid methyl ester (104574-03-0) → (2S,3S)-3-Chloromethyl-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester (40579-32-6,51446-86-7,75645-45-3,104640-64-4)

Guidance literature:

With copper dichloride; Yield given;

DOI:10.1016/S0040-4039(01)80900-X

upstream raw materials:

(S)-3,3-Dimethyl-4,7-dioxo-6-(2-phenoxy-acetylamino)-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester

2,5-Dimercapto-1,3,4-thiadiazole

Downstream raw materials:

(2S,3S)-3-Chloromethyl-3-methyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid methyl ester