<4S^*-(4α,4aα,7aα)>-4,4a,5,6,7,7a-hexahydro-4-methyl-7a-(4-morpholinyl)-3-phenyl-cyclopenta-1,2-oxazine N-oxide

Base Information

• Chemical Name: <4S^*-(4α,4aα,7aα)>-4,4a,5,6,7,7a-hexahydro-4-methyl-7a-(4-morpholinyl)-3-phenyl-cyclopenta-1,2-oxazine N-oxide
• CAS No.: 114390-75-9
• Molecular Formula: C₁₈H₂₄N₂O₃
• Molecular Weight: 316.4

Synonyms:

Chemical Property of <4S^*-(4α,4aα,7aα)>-4,4a,5,6,7,7a-hexahydro-4-methyl-7a-(4-morpholinyl)-3-phenyl-cyclopenta-1,2-oxazine N-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <4S^*-(4α,4aα,7aα)>-4,4a,5,6,7,7a-hexahydro-4-methyl-7a-(4-morpholinyl)-3-phenyl-cyclopenta-1,2-oxazine N-oxide

There total 2 articles about <4S^*-(4α,4aα,7aα)>-4,4a,5,6,7,7a-hexahydro-4-methyl-7a-(4-morpholinyl)-3-phenyl-cyclopenta-1,2-oxazine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-nitro-1-phenylmethane (622-42-4) → <4S*-(4α,4aα,7aα)>-4,4a,5,6,7,7a-hexahydro-4-methyl-7a-(4-morpholinyl)-3-phenyl-cyclopenta-1,2-oxazine N-oxide (114390-75-9)

Guidance literature:

Multi-step reaction with 3 steps

1: basic aluminium oxide / 1.) 0 deg C, 5 h, 2.) room temperature, 20 h

2: methanesulfonyl chloride, triethylamine / CH₂Cl₂ / 0.75 h / 0 °C

3: diethyl ether / 12 h / Ambient temperature

With aluminum oxide; methanesulfonyl chloride; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4020(01)90296-0

Reference yield:

1-nitro-1-phenyl-2-propanol (62634-59-7) → <4S*-(4α,4aα,7aα)>-4,4a,5,6,7,7a-hexahydro-4-methyl-7a-(4-morpholinyl)-3-phenyl-cyclopenta-1,2-oxazine N-oxide (114390-75-9)

Guidance literature:

Multi-step reaction with 2 steps

1: methanesulfonyl chloride, triethylamine / CH₂Cl₂ / 0.75 h / 0 °C

2: diethyl ether / 12 h / Ambient temperature

With methanesulfonyl chloride; triethylamine; In diethyl ether; dichloromethane;

DOI:10.1016/S0040-4020(01)90296-0

Reference yield:

<4S*-(4α,4aα,7aα)>-4,4a,5,6,7,7a-hexahydro-4-methyl-7a-(4-morpholinyl)-3-phenyl-cyclopenta-1,2-oxazine N-oxide (114390-75-9) → 4-[2-(1-Methyl-2-nitro-2-phenyl-ethyl)-cyclopent-1-enyl]-morpholine (114390-90-8,114390-91-9) + 4-<5-(1-methyl-2-nitroethyl-2-phenyl)-1-cyclopentenyl>-morpholine (114390-81-7,114421-95-3,114421-96-4,114421-97-5)

Guidance literature:

In chloroform-d1; Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)90296-0

upstream raw materials:

1-nitro-1-phenylmethane

1-nitro-1-phenyl-2-propanol

Downstream raw materials:

2-(1-methyl-2-nitroethyl-2-phenyl)-cyclopentanone

4-<5-(1-methyl-2-nitroethyl-2-phenyl)-1-cyclopentenyl>-morpholine

4-[2-(1-Methyl-2-nitro-2-phenyl-ethyl)-cyclopent-1-enyl]-morpholine

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