2-phenyl-3-amino-5-methylpyrrole hydrochloride

Base Information

• Chemical Name: 2-phenyl-3-amino-5-methylpyrrole hydrochloride
• CAS No.: 100856-20-0
• Molecular Formula: C₁₁H₁₂N₂*ClH
• Molecular Weight: 208.691

Synonyms:

Chemical Property of 2-phenyl-3-amino-5-methylpyrrole hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of 2-phenyl-3-amino-5-methylpyrrole hydrochloride

There total 1 articles about 2-phenyl-3-amino-5-methylpyrrole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-phenyl-3-amino-4-t-butoxycarbonyl-5-methylpyrrole hydrochloride (100856-19-7) → 2-phenyl-3-amino-5-methylpyrrole hydrochloride (100856-20-0)

Guidance literature:

In various solvent(s); 210-235 deg C bath temp., 15 min.;

DOI:10.1002/jhet.5570220323

Reference yield:

2-phenyl-3-amino-5-methylpyrrole hydrochloride (100856-20-0) → 1,5-Dimethyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid (100856-39-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium methylate / ethanol / 2 h / Ambient temperature

2: sodium hydride / tetrahydrofuran / 1.) reflux, 2 hrs, 2.) r.t., overnight

3: polyphosphoric ester / 2 h / 100 - 110 °C

4: 70 percent / sodium hydroxide (1 percent) / methanol; H₂O / heating on a boiling water bath, 1 hr.,

With sodium hydroxide; polyphosphoric ester; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; ethanol; water;

DOI:10.1002/jhet.5570220323

Reference yield:

2-phenyl-3-amino-5-methylpyrrole hydrochloride (100856-20-0) → 6-Allyl-1-benzyl-5-methyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid (100856-41-5)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium methylate / ethanol / 2 h / Ambient temperature

2: sodium hydride (60 percent) / tetrahydrofuran / 1.) reflux, 4 hrs., 2.) r.t., overnight

3: polyphosphoric ester / 2 h / 100 - 110 °C

4: 98.5 percent / sodium methoxide / dimethylformamide / r.t., overnight

5: 95 percent / sodium hydroxide (1 percent) / methanol; H₂O / heating on a boiling water bath, 1 hr.,

With sodium hydroxide; polyphosphoric ester; sodium methylate; sodium hydride; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570220323

upstream raw materials:

2-phenyl-3-amino-4-t-butoxycarbonyl-5-methylpyrrole hydrochloride

Downstream raw materials:

1,5-Dimethyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine-3-carboxylic acid

6-Allyl-1,5-dimethyl-4-oxo-7-phenyl-4,6-dihydro-1H-pyrrolo[3,4-b]pyridine-3-carboxylic acid

3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

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