C₂₁H₁₆O₂S

Base Information

• Chemical Name: C₂₁H₁₆O₂S
• CAS No.: 1135315-81-9
• Molecular Formula: C₂₁H₁₆O₂S
• Molecular Weight: 332.423
• Mol file: 1135315-81-9.mol

Synonyms:

Chemical Property of C₂₁H₁₆O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₆O₂S

There total 5 articles about C₂₁H₁₆O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H24O3S (1163701-47-0) → C21H16O2S (1135315-81-9)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/co200090p

Reference yield:

4-(3-iodo-1-benzothiophen-2-yl)phenyl methyl ether (1163701-22-1) → C21H16O2S (1135315-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere

2: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium carbonate; In tetrahydrofuran; ethanol; water; toluene; 1: Suzuki-Miyaura coupling;

DOI:10.1021/co200090p

Reference yield:

2-(methylthio)iodobenzene (33775-94-9) → C21H16O2S (1135315-81-9)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; triethylamine / 50 °C / Inert atmosphere

2: iodine / dichloromethane / 0.17 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; water; toluene / 80 °C / Inert atmosphere

4: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trans-bis(triphenylphosphine)palladium dichloride; water; iodine; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 1: Sonogashira reaction / 3: Suzuki-Miyaura coupling;

DOI:10.1021/co200090p

upstream raw materials:

4-(3-iodo-1-benzothiophen-2-yl)phenyl methyl ether

C₂₆H₂₄O₃S

2-(methylthio)iodobenzene

1-((4-methoxyphenyl)ethynyl)-2-(methylsulfanyl)benzene