Technology Process of 3-((1aS,2R,3aR,7aR,7bS)-6-Phenyl-hexahydro-1,3,5,7-tetraoxa-cyclopropa[a]naphthalen-2-yl)-propionaldehyde
There total 11 articles about 3-((1aS,2R,3aR,7aR,7bS)-6-Phenyl-hexahydro-1,3,5,7-tetraoxa-cyclopropa[a]naphthalen-2-yl)-propionaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 80 percent / d,l-camphorsulfonic acid / CH2Cl2 / Ambient temperature
2: 1.) diborane, 2.) 2N NaOH, 30percent H2O2 / 1.) THF, -25 deg C, 12 h, 2.) EtOH, RT, overnight
3: pyridine / Ambient temperature
4: MeOH, Dowex 50W (H+) / 9.5 h / Ambient temperature
5: MCPBA / CHCl3 / 5 °C
6: d,l-camphorsulfonic acid / CHCl3
7: sodium methoxide / methanol; tetrahydrofuran / 5 °C
8: 1.) DMSO, (COCl)2, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2, -78 deg C, 10 min.
With
pyridine; methanol; sodium hydroxide; oxalyl dichloride; Dowex 50W (H+); camphor-10-sulfonic acid; dihydrogen peroxide; sodium methylate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; diborane;
In
tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1016/S0040-4020(01)86916-7
- Guidance literature:
-
Multi-step reaction with 4 steps
1: MCPBA / CHCl3 / 5 °C
2: d,l-camphorsulfonic acid / CHCl3
3: sodium methoxide / methanol; tetrahydrofuran / 5 °C
4: 1.) DMSO, (COCl)2, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2, -78 deg C, 10 min.
With
oxalyl dichloride; camphor-10-sulfonic acid; sodium methylate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; methanol; chloroform;
DOI:10.1016/S0040-4020(01)86916-7
- Guidance literature:
-
Multi-step reaction with 3 steps
1: d,l-camphorsulfonic acid / CHCl3
2: sodium methoxide / methanol; tetrahydrofuran / 5 °C
3: 1.) DMSO, (COCl)2, 2.) triethylamine / 1.) CH2Cl2, -78 deg C, 2.) CH2Cl2, -78 deg C, 10 min.
With
oxalyl dichloride; camphor-10-sulfonic acid; sodium methylate; dimethyl sulfoxide; triethylamine;
In
tetrahydrofuran; methanol; chloroform;
DOI:10.1016/S0040-4020(01)86916-7
