(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester

Base Information

Chemical Name:(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester
CAS No.:110637-12-2
Molecular Formula:C₂₆H₃₅N₃O₆S
Molecular Weight:517.646
Hs Code.:

(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester

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Chemical Property of (2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester

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Technology Process of (2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester

There total 3 articles about (2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.9%

: 40439-01-8
hetacillin

: 110627-18-4
2-Chloromethoxymethyl-tetrahydro-pyran

: 110637-12-2
(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 5h; 1.) 0-5 deg C, 5 h, 2.) RT;
DOI:10.1248/cpb.35.2366

Reference yield:

: 100-72-1
Tetrahydropyran-2-methanol

: 110637-12-2
(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 13 percent / HCl / H₂O / 6 h / 5 °C

2: 53.9 percent / Et₃N / CH₂Cl₂ / 5 h / 1.) 0-5 deg C, 5 h, 2.) RT

With hydrogenchloride; triethylamine; In dichloromethane; water;
DOI:10.1248/cpb.35.2366

Reference yield:

: 33993-48-5
ampicillin

: 110637-12-2
(2S,5R,6R)-6-(2,2-Dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid tetrahydro-pyran-2-ylmethoxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 41.3 percent / 6M NaOH / H₂O / 1.) 35-40 deg C, 3 h, 2.) RT

2: 53.9 percent / Et₃N / CH₂Cl₂ / 5 h / 1.) 0-5 deg C, 5 h, 2.) RT

With sodium hydroxide; triethylamine; In dichloromethane; water;
DOI:10.1248/cpb.35.2366