Technology Process of 5,7-diamino-N5-<2-<4-(2-carboxyethyl)phenyl>ethyl>-3-(β-D-ribofuranosyl)imidazo<4,5-b>pyridine dihydrochloride
There total 8 articles about 5,7-diamino-N5-<2-<4-(2-carboxyethyl)phenyl>ethyl>-3-(β-D-ribofuranosyl)imidazo<4,5-b>pyridine dihydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 59 percent / borane-pyridine complex, acetic acid / petroleum ether / 2 h / Ambient temperature
2: 87 percent / triethylamine / CH2Cl2 / 18 h / Ambient temperature
3: phosphoryl chloride / acetonitrile / 48 h
4: ammonia / methanol
5: 80 percent / sodium hydride / dioxane / 1.5 h / Heating
6: 28 percent / tri-o-tolylphosphine, triethylamine / palladium acetate / 18 h / Heating
7: 80 percent / H2 / palladium hydroxide / aq. ethanol / 5 h / 60 °C / 2327.2 Torr
8: 1.) 90percent trifluoroacetic acid 2.) HCl gas / 1.) 1 h 2.) ether, 5 min
With
hydrogenchloride; borane pyridine; ammonia; hydrogen; sodium hydride; acetic acid; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; trichlorophosphate;
palladium dihydroxide; palladium diacetate;
In
1,4-dioxane; methanol; ethanol; dichloromethane; acetonitrile; Petroleum ether;
DOI:10.1139/v92-166
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 87 percent / triethylamine / CH2Cl2 / 18 h / Ambient temperature
2: phosphoryl chloride / acetonitrile / 48 h
3: ammonia / methanol
4: 80 percent / sodium hydride / dioxane / 1.5 h / Heating
5: 28 percent / tri-o-tolylphosphine, triethylamine / palladium acetate / 18 h / Heating
6: 80 percent / H2 / palladium hydroxide / aq. ethanol / 5 h / 60 °C / 2327.2 Torr
7: 1.) 90percent trifluoroacetic acid 2.) HCl gas / 1.) 1 h 2.) ether, 5 min
With
hydrogenchloride; ammonia; hydrogen; sodium hydride; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; trichlorophosphate;
palladium dihydroxide; palladium diacetate;
In
1,4-dioxane; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1139/v92-166
- Guidance literature:
-
Multi-step reaction with 6 steps
1: phosphoryl chloride / acetonitrile / 48 h
2: ammonia / methanol
3: 80 percent / sodium hydride / dioxane / 1.5 h / Heating
4: 28 percent / tri-o-tolylphosphine, triethylamine / palladium acetate / 18 h / Heating
5: 80 percent / H2 / palladium hydroxide / aq. ethanol / 5 h / 60 °C / 2327.2 Torr
6: 1.) 90percent trifluoroacetic acid 2.) HCl gas / 1.) 1 h 2.) ether, 5 min
With
hydrogenchloride; ammonia; hydrogen; sodium hydride; triethylamine; tris-(o-tolyl)phosphine; trifluoroacetic acid; trichlorophosphate;
palladium dihydroxide; palladium diacetate;
In
1,4-dioxane; methanol; ethanol; acetonitrile;
DOI:10.1139/v92-166
