Piperidine, 1-[[(phenylmethyl)amino]acetyl]-

Base Information

Chemical Name:Piperidine, 1-[[(phenylmethyl)amino]acetyl]-
CAS No.:100875-44-3
Molecular Formula:C14H20N2O
Molecular Weight:232.326
Hs Code.:
ChEMBL ID:CHEMBL176262
DSSTox Substance ID:DTXSID00472369
Wikidata:Q82301270
Mol file:100875-44-3.mol

Synonyms:100875-44-3;2-(benzylamino)-1-(piperidin-1-yl)ethan-1-one;Piperidine, 1-[[(phenylmethyl)amino]acetyl]-;CHEMBL176262;BDBM12453;DTXSID00472369;15.2b;AKOS000251939;AKOS002995184;N-Benzyl-2-oxo-2-(1-piperidinyl)ethaneamine

Suppliers and Price of Piperidine, 1-[[(phenylmethyl)amino]acetyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperidine, 1-[[(phenylmethyl)amino]acetyl]-

Chemical Property:

XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:232.157563266
Heavy Atom Count:17
Complexity:230

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(CC1)C(=O)CNCC2=CC=CC=C2

Technology Process of Piperidine, 1-[[(phenylmethyl)amino]acetyl]-

There total 7 articles about Piperidine, 1-[[(phenylmethyl)amino]acetyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1796-25-4
1-(2-bromoacetyl)piperidine

: 100-46-9
benzylamine

: 100875-44-3
1-(N-benzyl-glycyl)-piperidine

Guidance literature:: In N,N-dimethyl-formamide; at 0 - 24 ℃; for 12h;
DOI:10.1021/ja907184g

Reference yield:

: 753501-10-9
benzyl-(2-oxo-2-piperidin-1-yl-ethyl)-carbamic acid tert-butyl ester

: 100875-44-3
1-(N-benzyl-glycyl)-piperidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.25h;
DOI:10.1021/jm0495982

Reference yield:

: 42116-44-9
N-tert-butoxycarbonylbenzylamine

: 100875-44-3
1-(N-benzyl-glycyl)-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / tetrahydrofuran / 0.08 h / -78 °C

1.2: tetrahydrofuran; diethyl ether / 2 h / 20 °C

2.1: aq. KOH / methanol / 4 h / 20 °C

3.1: TBTU; diisopropylethylamine / CH₂Cl₂ / 3 h

4.1: trifluoroacetic acid / CH₂Cl₂ / 0.25 h

With potassium hydroxide; n-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm0495982