4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

Base Information

Chemical Name:4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one
CAS No.:155434-89-2
Molecular Formula:C₄₆H₅₂Br₃N₃O₁₇
Molecular Weight:1158.64
Hs Code.:

4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

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Chemical Property of 4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

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Technology Process of 4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

There total 12 articles about 4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50622-78-1
Benzyl 4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate

: 155434-89-2
4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / H₂ / Pd-on-charcoal / methanol / 4 h / Ambient temperature

2: oxalyl chloride / CH₂Cl₂ / 0.5 h

3: N,N-dimethylaniline / CH₂Cl₂ / 1.) room temperature, 30 min, 2.) reflux, 10 min

4: SO₂Cl₂ / CH₂Cl₂ / 0.25 h

5: AcONa / 1 h / 75 °C

6: 1.) stannic chloride, 2.) p-TsOH*H₂O, AgOAc / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) THF, room temperature, 12 h

With sulfuryl dichloride; oxalyl dichloride; hydrogen; silver(I) acetate; sodium acetate; tin(IV) chloride; toluene-4-sulfonic acid; N,N-dimethyl-aniline; palladium on activated charcoal; In methanol; dichloromethane;

Reference yield:

: 75975-54-1
tert-butyl 3,3'-bis<(methoxycarbonyl)methyl>-4,4'-bis<β-(methoxycarbonyl)ethyl>-5-<(benzyloxy)carbonyl>dipyrrylmethane-5-carboxylate

: 155434-89-2
4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / stannic chloride / CH₂Cl₂ / 1.5 h / 0 °C

2: 100 percent / NaHCO₃, I₂, KI / CH₂Cl₂; H₂O / 0.33 h

3: 1.) stannic chloride, 2.) p-TsOH*H₂O, AgOAc / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) THF, room temperature, 12 h

With iodine; silver(I) acetate; tin(IV) chloride; sodium hydrogencarbonate; toluene-4-sulfonic acid; potassium iodide; In dichloromethane; water;

Reference yield:

: 107751-49-5
4-(2-Methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-5-methyl-1H-pyrrole-2-carboxylic acid

: 155434-89-2
4-[5-benzyloxycarbonyl-4-(2-methoxycarbonylethyl)-3-(methoxycarbonylmethyl)pyrrol-2-ylmethyl]-2,7-bis-(2-methoxycarbonylethyl)-3,8-bis(methoxycarbonylmethyl)-9-(2,2,2-tribromoethoxycarbonyl)-4,5-dihydrodipyrrin-1(10H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride / CH₂Cl₂ / 0.5 h

2: N,N-dimethylaniline / CH₂Cl₂ / 1.) room temperature, 30 min, 2.) reflux, 10 min

3: SO₂Cl₂ / CH₂Cl₂ / 0.25 h

4: AcONa / 1 h / 75 °C

5: 1.) stannic chloride, 2.) p-TsOH*H₂O, AgOAc / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) THF, room temperature, 12 h

With sulfuryl dichloride; oxalyl dichloride; silver(I) acetate; sodium acetate; tin(IV) chloride; toluene-4-sulfonic acid; N,N-dimethyl-aniline; In dichloromethane;