(3-iodophenyl)methanesulfonyl chloride

Base Information

• Chemical Name: (3-iodophenyl)methanesulfonyl chloride
• CAS No.: 352708-55-5
• Molecular Formula: C₇H₆ClIO₂S
• Molecular Weight: 316.547
• Hs Code.: 2904990090
• Mol file: 352708-55-5.mol

Synonyms:

Chemical Property of (3-iodophenyl)methanesulfonyl chloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-iodophenyl)methanesulfonyl chloride

There total 3 articles about (3-iodophenyl)methanesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

sodium (3-iodophenyl)methanesulfonate (452340-19-1) → (3-iodophenyl)methanesulfonyl chloride (352708-55-5)

Guidance literature:

With trichlorophosphate; In sulfolane; acetonitrile; at 70 ℃; for 2h;

DOI:10.1021/jm801016j

Reference yield:

m-Iodobenzyl bromide (49617-83-6) → (3-iodophenyl)methanesulfonyl chloride (352708-55-5)

Guidance literature:

m-Iodobenzyl bromide; With sodium hydroxide; sodium sulfite; In water; acetone; for 4h; Reflux;

With thionyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/j.ejmech.2013.04.013

Reference yield:

→ (3-iodophenyl)methanesulfonyl chloride (352708-55-5)

Guidance literature:

Na-Salz von m-Iodbenzylsulfonsaeure, PCl5;

DOI:10.1007/BF01199621

upstream raw materials:

sodium (3-iodophenyl)methanesulfonate

m-Iodobenzyl bromide

Refernces

• 1、 Procopiou, Panayiotis A.,Barrett, Victoria J.,Bevan, Nicola J.,Biggadike, Keith,Butchers, Peter R.,Coe, Diane M.,Conroy, Richard,Edney, Dean D.,Field, Rita N.,Ford, Alison J.,Guntrip, Stephen B.,Looker, Brian E.,McLay, Iain M.,Monteith, Michael J.,Morrison, Valerie S.,Mutch, Peter J.,Richards, Stephen A.,Sasse, Rosemary,Smith, Claire E.. "Synthesis and structure-activity relationships of long-acting β2 adrenergic receptor agonists incorporating arylsulfonamide groups". supporting information; experimental part. p. 2280 - 2288. Retrieved 2010/03/25.