benzhydryl 7β-amino-3-azidomethyl-3-cephem-4-carboxylate-1,1-dioxide

Base Information

Chemical Name:benzhydryl 7β-amino-3-azidomethyl-3-cephem-4-carboxylate-1,1-dioxide
CAS No.:147135-84-0
Molecular Formula:C₂₁H₁₉N₅O₅S
Molecular Weight:453.478
Hs Code.:

Synonyms:

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Chemical Property of benzhydryl 7β-amino-3-azidomethyl-3-cephem-4-carboxylate-1,1-dioxide

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Technology Process of benzhydryl 7β-amino-3-azidomethyl-3-cephem-4-carboxylate-1,1-dioxide

There total 1 articles about benzhydryl 7β-amino-3-azidomethyl-3-cephem-4-carboxylate-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3994-82-9
7β-amino-3-azidomethyl-3-cephem-4-carboxylic acid

: 908093-98-1
diazodiphenylmethane

: 147135-84-0
benzhydryl 7β-amino-3-azidomethyl-3-cephem-4-carboxylate-1,1-dioxide

Guidance literature:: With sodium tungstate; dihydrogen peroxide; Yield given. Multistep reaction; 1.) DMSO, CH₂Cl₂, room temperature, 68 h, 2.) EtOAc, 0 deg C, 15 min; room temperature, overnight;
DOI:10.1135/cccc19942282

Reference yield:

: 147135-84-0
benzhydryl 7β-amino-3-azidomethyl-3-cephem-4-carboxylate-1,1-dioxide

: benzhydryl 7α-methoxy-2-exo-methylene-3-<(1,2,3-triazolyl)methyl>-3-cephem-4-carboxylate-1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaNO₂, H₂SO₄, 2.) rhodium acetate dimer / 1.) CH₂Cl₂, H₂O, 0 deg C, 1 h, 2.) room temperature, 1 h

2: 58 percent / 1,2-dimethoxy-ethane / 90 °C

3: 49 percent / dimethylammonium chloride / CH₂Cl₂; 2-methyl-propan-2-ol; H₂O / 1.5 h / 80 °C

With dirhodium tetraacetate; sulfuric acid; N,N-dimethylammonium chloride; sodium nitrite; In 1,2-dimethoxyethane; dichloromethane; water; tert-butyl alcohol;
DOI:10.1135/cccc19942282

Reference yield:

: 147135-84-0
benzhydryl 7β-amino-3-azidomethyl-3-cephem-4-carboxylate-1,1-dioxide

: 147135-86-2
benzhydryl 7α-methoxy-3-<(1,2,3-triazolyl)methyl>-3-cephem-4-carboxylate-1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaNO₂, H₂SO₄, 2.) rhodium acetate dimer / 1.) CH₂Cl₂, H₂O, 0 deg C, 1 h, 2.) room temperature, 1 h

2: 58 percent / 1,2-dimethoxy-ethane / 90 °C

With dirhodium tetraacetate; sulfuric acid; sodium nitrite; In 1,2-dimethoxyethane;
DOI:10.1135/cccc19942282