2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester

Base Information

Chemical Name:2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester
CAS No.:105224-69-9
Molecular Formula:C₂₃H₃₀N₄O₄S
Molecular Weight:458.582
Hs Code.:

2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester

Synonyms:

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Chemical Property of 2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester

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Technology Process of 2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester

There total 1 articles about 2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105224-68-8
2-((R)-1-{[(4S,5R)-2-((S)-1-tert-Butoxycarbonylamino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester

: 105224-69-9
2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 1h; Yield given;
DOI:10.1016/S0040-4039(00)83967-2

Reference yield:

: 105224-69-9
2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester

: 105224-72-4
2-((R)-1-{[(4S,5R)-2-((S)-1-tert-Butoxycarbonylamino-3-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-ethyl)-thiazole-4-carboxylic acid

: 105224-73-5
C₄₄H₆₀N₈O₉S₂

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 0 ℃; for 14h; Yield given;
DOI:10.1016/S0040-4039(00)83967-2

Reference yield:

: 105224-69-9
2-((R)-1-{[(4S,5R)-2-((S)-1-Amino-2-methyl-butyl)-5-methyl-4,5-dihydro-oxazole-4-carbonyl]-amino}-2-phenyl-ethyl)-thiazole-4-carboxylic acid methyl ester

: 105242-53-3
C₄₄H₄₉F₅N₈O₇S₂

Guidance literature:: Multi-step reaction with 3 steps

1: diphenyl phosphorazidate, Et₃N / dioxane / 14 h / 0 °C

2: 1.) NaOH, 2.) DCCD / 1.) dioxane, H₂O, room temperature, 1 h, 2.) dioxane, from 0 grad C to room temperature

3: trifluoroacetic acid / 1 h / 0 °C

With sodium hydroxide; diphenyl phosphoryl azide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane;
DOI:10.1016/S0040-4039(00)83967-2