Methyl 3β-tosyloxy-7α-hydroxy-12-oxo-5α-cholanate

Base Information

Chemical Name:Methyl 3β-tosyloxy-7α-hydroxy-12-oxo-5α-cholanate
CAS No.:110674-08-3
Molecular Formula:C₃₂H₄₆O₇S
Molecular Weight:574.779
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 3β-tosyloxy-7α-hydroxy-12-oxo-5α-cholanate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:: SDS file from LookChem

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Technology Process of Methyl 3β-tosyloxy-7α-hydroxy-12-oxo-5α-cholanate

There total 6 articles about Methyl 3β-tosyloxy-7α-hydroxy-12-oxo-5α-cholanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 110674-06-1
Methyl 3β,7α-dihydroxy-12-oxo-5α-cholanate

: 98-59-9
p-toluenesulfonyl chloride

: 110674-08-3
Methyl 3β-tosyloxy-7α-hydroxy-12-oxo-5α-cholanate

Guidance literature:: With pyridine; for 24h; Ambient temperature;
DOI:10.1055/s-1986-31848

Reference yield:

: 14772-93-1
methyl 3β,7α,12α-trihydroxy-5α-cholan-24-oate

: 110674-08-3
Methyl 3β-tosyloxy-7α-hydroxy-12-oxo-5α-cholanate

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / 4-dimethylaminopyridine / benzene; pyridine / 0.08 h / Ambient temperature

2: 96 percent / K₂CrO₄ / acetic acid; H₂O / Ambient temperature

3: 100 percent / KOH / methanol / 12 h / Heating

4: p-toluenesulfonic acid / Ambient temperature

5: 88 percent / pyridine / 24 h / Ambient temperature

With pyridine; dmap; potassium hydroxide; potassium chromate; toluene-4-sulfonic acid; In pyridine; methanol; water; acetic acid; benzene;
DOI:10.1055/s-1986-31848

Reference yield:

: 13587-11-6
3-oxo-7α,12α-dihydroxy-4-cholen-24-oic acid

: 110674-08-3
Methyl 3β-tosyloxy-7α-hydroxy-12-oxo-5α-cholanate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) Li/NH₃

2: 86 percent / 4-dimethylaminopyridine / benzene; pyridine / 0.08 h / Ambient temperature

3: 96 percent / K₂CrO₄ / acetic acid; H₂O / Ambient temperature

4: 100 percent / KOH / methanol / 12 h / Heating

5: p-toluenesulfonic acid / Ambient temperature

6: 88 percent / pyridine / 24 h / Ambient temperature

With pyridine; dmap; potassium hydroxide; potassium chromate; ammonia; lithium; toluene-4-sulfonic acid; In pyridine; methanol; water; acetic acid; benzene;
DOI:10.1055/s-1986-31848