Isobutyric acid 4-acetoxy-2-[(2S,3R)-5-acetoxy-2-(acetyl-methyl-amino)-3-methyl-2,3-dihydro-benzofuran-3-yl]-phenyl ester

Base Information

• Chemical Name: Isobutyric acid 4-acetoxy-2-[(2S,3R)-5-acetoxy-2-(acetyl-methyl-amino)-3-methyl-2,3-dihydro-benzofuran-3-yl]-phenyl ester
• CAS No.: 104816-18-4
• Molecular Formula: C₂₆H₂₉NO₈
• Molecular Weight: 483.518
• Mol file: 104816-18-4.mol

Synonyms:

Chemical Property of Isobutyric acid 4-acetoxy-2-[(2S,3R)-5-acetoxy-2-(acetyl-methyl-amino)-3-methyl-2,3-dihydro-benzofuran-3-yl]-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isobutyric acid 4-acetoxy-2-[(2S,3R)-5-acetoxy-2-(acetyl-methyl-amino)-3-methyl-2,3-dihydro-benzofuran-3-yl]-phenyl ester

There total 3 articles about Isobutyric acid 4-acetoxy-2-[(2S,3R)-5-acetoxy-2-(acetyl-methyl-amino)-3-methyl-2,3-dihydro-benzofuran-3-yl]-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + Isobutyric acid 4-hydroxy-2-((2R,3S)-5-hydroxy-3-methyl-2-methylamino-2,3-dihydro-benzofuran-3-yl)-phenyl ester (82334-14-3) → Isobutyric acid 4-acetoxy-2-[(2S,3R)-5-acetoxy-2-(acetyl-methyl-amino)-3-methyl-2,3-dihydro-benzofuran-3-yl]-phenyl ester (104816-18-4)

Guidance literature:

In pyridine; at -15 ℃; for 48h; Yield given;

DOI:10.1016/0040-4020(82)80202-0

Reference yield:

(E)-2,4-Dimethyl-1-methylamino-pent-1-en-3-one (104816-12-8) → Isobutyric acid 4-acetoxy-2-[(2S,3R)-5-acetoxy-2-(acetyl-methyl-amino)-3-methyl-2,3-dihydro-benzofuran-3-yl]-phenyl ester (104816-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene; CCl₄ / -20 °C

2: pyridine / 48 h / -15 °C

In pyridine; tetrachloromethane; benzene;

DOI:10.1016/0040-4020(82)80202-0

Reference yield:

p-benzoquinone (106-51-4) → Isobutyric acid 4-acetoxy-2-[(2S,3R)-5-acetoxy-2-(acetyl-methyl-amino)-3-methyl-2,3-dihydro-benzofuran-3-yl]-phenyl ester (104816-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene; CCl₄ / -20 °C

2: pyridine / 48 h / -15 °C

In pyridine; tetrachloromethane; benzene;

DOI:10.1016/0040-4020(82)80202-0

upstream raw materials:

acetic anhydride

Isobutyric acid 4-hydroxy-2-((2R,3S)-5-hydroxy-3-methyl-2-methylamino-2,3-dihydro-benzofuran-3-yl)-phenyl ester

(E)-2,4-Dimethyl-1-methylamino-pent-1-en-3-one

p-benzoquinone