2-(2-HYDROXYPHENYL)-5-METHYL-1H-BENZOIMIDAZOLE

Base Information

• Chemical Name: 2-(2-HYDROXYPHENYL)-5-METHYL-1H-BENZOIMIDAZOLE
• CAS No.: 6266-09-7
• Molecular Formula: C14H12 N2 O
• Molecular Weight: 224.262
• Hs Code.: 2933990090
• Mol file: 6266-09-7.mol

Synonyms:Phenol,2-(5-methyl-1H-benzimidazol-2-yl)- (9CI); Phenol,o-(5-methyl-2-benzimidazolyl)- (6CI,8CI); 2-(2-Hydroxyphenyl)-5-methyl-1H-benzimidazole;NSC 32820

Chemical Property of 2-(2-HYDROXYPHENYL)-5-METHYL-1H-BENZOIMIDAZOLE

Chemical Property:

• Vapor Pressure: 2.16E-06mmHg at 25°C
• Boiling Point: 393.2°C at 760 mmHg
• Flash Point: 162.4°C
• PSA: 48.91000
• Density: 1.25g/cm³
• LogP: 3.24390

Purity/Quality:

2-(2-HYDROXYPHENYL)-5-METHYL-1H-BENZOIMIDAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-HYDROXYPHENYL)-5-METHYL-1H-BENZOIMIDAZOLE

There total 10 articles about 2-(2-HYDROXYPHENYL)-5-METHYL-1H-BENZOIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

salicylaldehyde (90-02-8) + 4-methyl-1,2-diaminobenzene (496-72-0) → 2-(5(6)-methyl-1H-benzoimidazol-2-yl)-phenol (6266-09-7)

Guidance literature:

With hydrogenchloride; dihydrogen peroxide; In acetonitrile; at 20 ℃; for 0.583333h;

DOI:10.1055/s-2007-965878

Reference yield: 90.0%

4-methyl-1,2-diaminobenzene (496-72-0) + 4-Chloro-2,2-diethyl-2H-benzo[e][1,3]oxazine (74405-11-1) → 2-(5(6)-methyl-1H-benzoimidazol-2-yl)-phenol (6266-09-7)

Guidance literature:

In acetonitrile; for 2h; Heating;

DOI:10.1021/jm00384a035

Reference yield: 85.0%

2-methyl-benzyl alcohol (89-95-2) + 4-methyl-1,2-diaminobenzene (496-72-0) → 2-(5(6)-methyl-1H-benzoimidazol-2-yl)-phenol (6266-09-7)

Guidance literature:

With manganese triacetate; acetic acid; at 20 ℃; for 12h;

DOI:10.1002/jhet.5570410309

upstream raw materials:

4-methyl-1,2-diaminobenzene

4-Chloro-2,2-diethyl-2H-benzo[e][1,3]oxazine

2-methyl-benzyl alcohol

salicylaldehyde

Downstream raw materials:

1-[4-Hydroxy-3-(5-methyl-1H-benzoimidazol-2-yl)-phenyl]-nonan-1-one

1-[4-Hydroxy-3-(5-methyl-1H-benzoimidazol-2-yl)-phenyl]-octan-1-one

1-[4-Hydroxy-3-(5-methyl-1H-benzoimidazol-2-yl)-phenyl]-heptan-1-one