Technology Process of (+/-)-10-epi-desmethoxyabresoline
There total 9 articles about (+/-)-10-epi-desmethoxyabresoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
1.) 0 degC, 1 h, 2.) r.t., 2 h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: yellow HgO / CH2Cl2 / 1.5 h / -10 - 0 °C
2: 99.1 percent / toluene / 2.5 h / Heating
3: 1.) methanesulfonyl chloride, 2.) 50percent AcOH, Zn / 1.) pyridine, 0 degC, 40 min, r.t. 1.5 h, 2.) H2O, r.t., 2 h
4: 72.7 percent / 4-dimethylaminopyridine / pyridine / 14 h / Ambient temperature
5: 68.5 percent / trifluoroacetic acid / CH2Cl2 / 1.) 0 degC, 1 h, 2.) r.t., 2 h
With
dmap; acetic acid; methanesulfonyl chloride; trifluoroacetic acid; mercury(II) oxide; zinc;
In
pyridine; dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 99.1 percent / toluene / 2.5 h / Heating
2: 1.) methanesulfonyl chloride, 2.) 50percent AcOH, Zn / 1.) pyridine, 0 degC, 40 min, r.t. 1.5 h, 2.) H2O, r.t., 2 h
3: 72.7 percent / 4-dimethylaminopyridine / pyridine / 14 h / Ambient temperature
4: 68.5 percent / trifluoroacetic acid / CH2Cl2 / 1.) 0 degC, 1 h, 2.) r.t., 2 h
With
dmap; acetic acid; methanesulfonyl chloride; trifluoroacetic acid; zinc;
In
pyridine; dichloromethane; toluene;
![(E)-3-[4-(2-Methoxy-ethoxymethoxy)-phenyl]-acrylic acid (2R,4R,9aS)-4-[4-methoxy-3-(2-methoxy-ethoxymethoxy)-phenyl]-octahydro-quinolizin-2-yl ester](/Databaselist/images/loading.webp)
