(2R,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Base Information

Chemical Name:(2R,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide
CAS No.:105943-75-7
Molecular Formula:C₃₄H₅₈N₄O₅
Molecular Weight:602.858
Hs Code.:

(2R,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

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Chemical Property of (2R,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

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Technology Process of (2R,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

There total 20 articles about (2R,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: Acetic acid (1S,2S)-4-methyl-1-{(S)-2-[(S)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-3-phenyl-propyl}-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-pentyl ester

: 105943-75-7,106032-75-1
(2S,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Guidance literature:: With potassium carbonate; In methanol;

Reference yield: 87.0%

: Acetic acid (1S,2S)-4-methyl-1-{(R)-2-[(S)-1-(3-methyl-butylcarbamoyl)-ethylcarbamoyl]-3-phenyl-propyl}-2-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-pentyl ester

: 105943-75-7,106032-75-1
(2R,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Guidance literature:: With potassium carbonate; In methanol;

Reference yield:

: 88481-75-8
(R)-2-<(phenylmethoxy)methyl>-3-benzenepropanol

: 105943-75-7,106032-75-1
(2R,4S,5S)-2-Benzyl-4-hydroxy-7-methyl-5-[(S)-3-methyl-2-(3-methyl-butyrylamino)-butyrylamino]-octanoic acid [(S)-1-(3-methyl-butylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 11 steps

1: 80 percent / PPh₃, NBS / CH₂Cl₂ / 15 h / Ambient temperature

2: 1.) Mg / 1.) THF, 4 h, 2.) THF, RT, 4 h

3: HCl / dioxane / 0.5 h

4: NEt₃ / CH₂Cl₂ / 6 h / 0 °C

5: 100 percent / NEt₃, 4-(dimethylamino)pyridine / ethyl acetate / 5 h / Ambient temperature

6: 95 percent / HCOONH₂, AcOH / 10percent Pd/C / propan-2-ol

7: pyridinium dichromate / dimethylformamide / 35 h

8: NEt₃, HOBt*H₂O, DCC / CH₂Cl₂ / 0 - 20 °C

9: HCl / dioxane

10: NEt₃ / dimethylformamide

11: 87 percent / K₂CO₃ / methanol

With hydrogenchloride; dmap; N-Bromosuccinimide; dipyridinium dichromate; HCOONH₂; potassium carbonate; benzotriazol-1-ol; magnesium; acetic acid; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;