Technology Process of (3S,4RS)-3-<amino>-4-oxo-5-phenoxypentanoic acid tert-butyl ester
There total 6 articles about (3S,4RS)-3-<amino>-4-oxo-5-phenoxypentanoic acid tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 77 percent / 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-dimethylaminopropylcarbodiimide monohydrochloride / CH2Cl2 / 12 h / Ambient temperature
2: 98 percent / H2 / 10 percent Pd/C / methanol / Ambient temperature
3: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-dimethylaminopropylcarbodiimide monohydrochloride / dimethylformamide / 8 h / Ambient temperature
4: Dess-Martin periodinane / CH2Cl2 / 1 h
With
4-methyl-morpholine; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.11
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 77 percent / 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-dimethylaminopropylcarbodiimide monohydrochloride / CH2Cl2 / 12 h / Ambient temperature
2: 98 percent / H2 / 10 percent Pd/C / methanol / Ambient temperature
3: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-dimethylaminopropylcarbodiimide monohydrochloride / dimethylformamide / 8 h / Ambient temperature
4: Dess-Martin periodinane / CH2Cl2 / 1 h
With
4-methyl-morpholine; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.11
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98 percent / H2 / 10 percent Pd/C / methanol / Ambient temperature
2: 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-dimethylaminopropylcarbodiimide monohydrochloride / dimethylformamide / 8 h / Ambient temperature
3: Dess-Martin periodinane / CH2Cl2 / 1 h
With
4-methyl-morpholine; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.47.11
