Technology Process of Antibiotic A 201A
There total 22 articles about Antibiotic A 201A which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
methanol; dichloromethane;
at 20 ℃;
for 5h;
Inert atmosphere;
DOI:10.1021/ja501460j
- Guidance literature:
-
With
sodium methylate;
In
methanol; dichloromethane;
at 20 ℃;
for 8h;
Inert atmosphere;
DOI:10.1021/ja501460j
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: pyridine / 1.5 h / 20 °C / Inert atmosphere
2.1: triphenylphosphine; silica gel; water / tetrahydrofuran / 4 h / 20 - 50 °C / Inert atmosphere
3.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
4.1: triethylamine / dichloromethane / 5 h / 20 °C / Inert atmosphere
5.1: lithium borohydride / tetrahydrofuran / -40 - 20 °C / Inert atmosphere
6.1: dichloromethane / 1 h / 20 °C / Inert atmosphere; Molecular sieve
6.2: 1.5 h / 0 °C / Inert atmosphere; Molecular sieve
7.1: sodium methylate / methanol; dichloromethane / 8 h / 20 °C / Inert atmosphere
With
pyridine; lithium borohydride; water; sodium methylate; silica gel; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja501460j
