4-methoxy-1-oxido-2-pyridylmethyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate

Base Information

Chemical Name:4-methoxy-1-oxido-2-pyridylmethyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate
CAS No.:1332729-43-7
Molecular Formula:C₅₂H₅₅N₆O₁₆P
Molecular Weight:1051.01
Hs Code.:

4-methoxy-1-oxido-2-pyridylmethyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate

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Chemical Property of 4-methoxy-1-oxido-2-pyridylmethyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate

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Technology Process of 4-methoxy-1-oxido-2-pyridylmethyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate

There total 7 articles about 4-methoxy-1-oxido-2-pyridylmethyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332729-31-3
diisopropyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate

: 1332729-43-7
4-methoxy-1-oxido-2-pyridylmethyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 2,6-dimethylpyridine; trimethylsilyl bromide / acetonitrile / 16 h / 20 °C

2: pyridine; dicyclohexyl-carbodiimide / 72 h / 20 °C

3: pyridine; water / 16 h / 50 °C

With pyridine; 2,6-dimethylpyridine; trimethylsilyl bromide; water; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1039/c1ob05488k

Reference yield:

: C₃₀H₄₂N₅O₁₂P

: 1332729-43-7
4-methoxy-1-oxido-2-pyridylmethyl [2-O-benzoyloxymethoxymethyl-3-O-dimethoxytrityl-1-(2-N-isobutyrylguanin-9-yl)-β-D-ribofuranos-5-O-yl]methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine; silver trifluoromethanesulfonate / 16 h / 20 °C

2: 2,6-dimethylpyridine; trimethylsilyl bromide / acetonitrile / 16 h / 20 °C

3: pyridine; dicyclohexyl-carbodiimide / 72 h / 20 °C

4: pyridine; water / 16 h / 50 °C

With pyridine; 2,6-dimethylpyridine; trimethylsilyl bromide; water; silver trifluoromethanesulfonate; dicyclohexyl-carbodiimide; In acetonitrile;
DOI:10.1039/c1ob05488k