Technology Process of 1-(3,5-dimethoxyphenyl)-1,2-bis(2-methylbenzofuran-3-yl)-2-oxoethyl acetate
There total 6 articles about 1-(3,5-dimethoxyphenyl)-1,2-bis(2-methylbenzofuran-3-yl)-2-oxoethyl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: tin(IV) chloride / benzene / 20 °C / Inert atmosphere
3.1: pyridine; copper(ll) sulfate pentahydrate / 1,4-dioxane; water / 2 h / Reflux
4.1: magnesium; ethylene dibromide / tetrahydrofuran / Reflux
4.2: 20 °C
5.1: dmap / tetrahydrofuran / 2 h / 0 - 20 °C
With
pyridine; dmap; n-butyllithium; copper(ll) sulfate pentahydrate; tin(IV) chloride; magnesium; ethylene dibromide;
In
tetrahydrofuran; 1,4-dioxane; hexane; water; benzene;
DOI:10.1002/anie.201108336
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tin(IV) chloride / benzene / 20 °C / Inert atmosphere
2.1: pyridine; copper(ll) sulfate pentahydrate / 1,4-dioxane; water / 2 h / Reflux
3.1: magnesium; ethylene dibromide / tetrahydrofuran / Reflux
3.2: 20 °C
4.1: dmap / tetrahydrofuran / 2 h / 0 - 20 °C
With
pyridine; dmap; copper(ll) sulfate pentahydrate; tin(IV) chloride; magnesium; ethylene dibromide;
In
tetrahydrofuran; 1,4-dioxane; water; benzene;
DOI:10.1002/anie.201108336