tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

Chemical Name:tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
CAS No.:936125-24-5
Molecular Formula:C₄₃H₆₆N₆O₁₀
Molecular Weight:827.031
Hs Code.:

tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Chemical Property of tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Technology Process of tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 6 articles about tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(2-amino-ethyl)-3,5-bis-prop-2-ynyloxy-benzamide; compound with trifluoro-acetic acid

: 137076-54-1
1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid

: 936125-24-5
tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1039/b615940k

Reference yield:

: 664334-21-8
3,5-bis(prop-2-yn-1-yloxy) benzoic acid

: 936125-24-5
tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / BOP; N,N-diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

2: CH₂Cl₂ / 1 h / 20 °C

3: 250 mg / BOP; N,N-diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1039/b615940k

Reference yield:

: 936125-20-1
tert-butyl 2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylcarbamate

: 936125-24-5
tert-butyl 2,2',2''-(10-(2-(2-(3,5-bis(prop-2-ynyloxy)benzamido)ethylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / 20 °C

2: 250 mg / BOP; N,N-diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1039/b615940k