(+)-phenopyrrozin

Base Information

Chemical Name:(+)-phenopyrrozin
CAS No.:1367352-71-3
Molecular Formula:C₁₃H₁₃NO₂
Molecular Weight:215.252
Hs Code.:

Synonyms:

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Chemical Property of (+)-phenopyrrozin

Chemical Property:

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Technology Process of (+)-phenopyrrozin

There total 7 articles about (+)-phenopyrrozin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1367352-87-1
C₁₃H₁₅NO

: 1367352-71-3
(+)-phenopyrrozin

Guidance literature:: C₁₃H₁₅NO; With N,N,N,N,N,N-hexamethylphosphoric triamide; oxygen; lithium diisopropyl amide; phosphorous acid trimethyl ester; In tetrahydrofuran; at -75 - -65 ℃; for 4h;

With sodium sulfite;
DOI:10.1016/j.tetlet.2012.01.098

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1367352-71-3
(+)-phenopyrrozin

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 0 - 20 °C

1.2: 22 h / 50 °C

2.1: triethylamine / tetrahydrofuran / 4 h / -65 - -40 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 0.67 h / 0 - 60 °C

4.1: Pd-BaSO₄; hydrogen / ethyl acetate / 20 °C

5.1: water; trifluoroacetic acid / dichloromethane / 2 h

6.1: ammonia / water / 0.67 h / 75 °C / sealed tube

7.1: N,N,N,N,N,N-hexamethylphosphoric triamide; oxygen; lithium diisopropyl amide; phosphorous acid trimethyl ester / tetrahydrofuran / 4 h / -75 - -65 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Pd-BaSO₄; ammonia; water; hydrogen; oxygen; sodium carbonate; triethylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium diisopropyl amide; phosphorous acid trimethyl ester; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 3.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2012.01.098

Reference yield:

: 1367352-85-9
C₂₀H₂₉NO₄

: 1367352-71-3
(+)-phenopyrrozin

Guidance literature:: Multi-step reaction with 3 steps

1: water; trifluoroacetic acid / dichloromethane / 2 h

2: ammonia / water / 0.67 h / 75 °C / sealed tube

3: N,N,N,N,N,N-hexamethylphosphoric triamide; oxygen; lithium diisopropyl amide; phosphorous acid trimethyl ester / tetrahydrofuran / 4 h / -75 - -65 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonia; water; oxygen; trifluoroacetic acid; lithium diisopropyl amide; phosphorous acid trimethyl ester; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tetlet.2012.01.098