Technology Process of C26H21ClN6O
There total 9 articles about C26H21ClN6O which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one;
at 80 ℃;
for 10h;
Inert atmosphere;
DOI:10.1021/ml300134b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere; Molecular sieve
1.2: Inert atmosphere; Reflux
2.1: triethylamine / 1-methyl-pyrrolidin-2-one / 2 h / 60 °C / Inert atmosphere
3.1: hydrogenchloride / 1-methyl-pyrrolidin-2-one; 1,4-dioxane / 10 h / 80 °C / Inert atmosphere
With
hydrogenchloride; sodium hydride; triethylamine;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1021/ml300134b
- Guidance literature:
-
Multi-step reaction with 6 steps
1: hydrogenchloride / butan-1-ol / 48 h / Molecular sieve; Reflux; Inert atmosphere
2: Dowtherm A / 2 h / 250 °C / Inert atmosphere
3: trichlorophosphate / 4 h / 110 °C / Inert atmosphere
4: sodium azide / 1-methyl-pyrrolidin-2-one / 18 h / 60 °C / Inert atmosphere
5: tin(ll) chloride; ethanol / ethyl acetate / 2 h / Reflux; Inert atmosphere
6: hydrogenchloride / 1-methyl-pyrrolidin-2-one; 1,4-dioxane / 10 h / 80 °C / Inert atmosphere
With
hydrogenchloride; sodium azide; ethanol; Dowtherm A; tin(ll) chloride; trichlorophosphate;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethyl acetate; butan-1-ol;
DOI:10.1021/ml300134b
