2H-Indol-2-one, 1,3-dihydro-3,5-dimethyl-

Base Information

• Chemical Name: 2H-Indol-2-one, 1,3-dihydro-3,5-dimethyl-
• CAS No.: 101349-15-9
• Molecular Formula: C10H11NO
• Molecular Weight: 161.20000
• Mol file: 101349-15-9.mol

Synonyms:2H-INDOL-2-ONE,1,3-DIHYDRO-3,5-DIMETHYL-;3,5-dimethyl-2-indolinone;1,3-DIHYDRO-3,5-DIMETHYL-2H-INDOL-2-ONE;3,5-dimethyl-indolin-2-one;3,5-Dimethyl-indolin-2-on;

Chemical Property of 2H-Indol-2-one, 1,3-dihydro-3,5-dimethyl-

Chemical Property:

• PSA: 29.10000
• LogP: 2.18860

Purity/Quality:

97% ^*data from raw suppliers

1,3-dihydro-3,5-dimethyl-2H-Indol-2-one 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-Indol-2-one, 1,3-dihydro-3,5-dimethyl-

There total 9 articles about 2H-Indol-2-one, 1,3-dihydro-3,5-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methyl α-methyl-5-methyl-2-nitrobenzeneacetate (92671-30-2) → 3,5-dimethyl-2-indolinone (101349-15-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; under 2068.6 - 2585.7 Torr; Ambient temperature;

DOI:10.1021/jo00360a014

Reference yield: 83.0%

3,5-dimethyl-1H-indole (3189-12-6) → 3,5-dimethyl-2-indolinone (101349-15-9)

Guidance literature:

With tetrabutyl-ammonium chloride; water; bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; at 25 ℃;

DOI:10.1002/adsc.202100234

Reference yield: 83.0%

5-methylindolin-2-one (3484-35-3) → 3,5-dimethyl-2-indolinone (101349-15-9)

Guidance literature:

5-methylindolin-2-one; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

methyl halide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.201700851

upstream raw materials:

3,5-dimethyl-1H-indole

methyl α-methyl-5-methyl-2-nitrobenzeneacetate

1-methyl-4-nitrobenzene

N-(2-bromo-4-methylphenyl)formamide

Downstream raw materials:

(R)-5-methyl-3-(hydroxy(phenyl)amino)-3-methylindolin-2-one