2-Hydroxy-8-methylquinoline-3-carbaldehyde

Base Information

• Chemical Name: 2-Hydroxy-8-methylquinoline-3-carbaldehyde
• CAS No.: 101382-54-1
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Hs Code.: 2933499090
• European Community (EC) Number: 802-495-6
• DSSTox Substance ID: DTXSID20354996
• Nikkaji Number: J2.488.238A
• Wikidata: Q82133555
• Mol file: 101382-54-1.mol

Synonyms:101382-54-1;2-hydroxy-8-methylquinoline-3-carbaldehyde;8-methyl-2-oxo-1H-quinoline-3-carbaldehyde;8-Methyl-2-oxo-1,2-dihydro-quinoline-3-carbaldehyde;2-Hydroxy-8-methyl-quinoline-3-carbaldehyde;8-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde;Oprea1_314969;Oprea1_867303;F0805-0002;SCHEMBL4071083;DTXSID20354996;BCP33154;BBL029813;MFCD02995894;STK826028;STL015205;AKOS000365927;AKOS004117354;SB67630;8-methyl-2-oxoquinoline-3-carbaldehyde;AM802838;AS-69682;2-Hydroxy-8-methyl-3-quinoline carbaldehyde;2-hydroxy-8-methylquinoline-3-carboxaldehyde;CS-0038798;FT-0764583;EN300-717252;W10343;2-Hydroxy-8-methylquinoline-3-carbaldehyde AldrichCPR;8-Methyl-2-Oxo-1,2-Dihydro-3-Quinolinecarbaldehyde;Z57116418;2-Hydroxy-8-methylquinoline-3-carbaldehyde, AldrichCPR

Chemical Property of 2-Hydroxy-8-methylquinoline-3-carbaldehyde

Chemical Property:

• Vapor Pressure: 2.59E-07mmHg at 25°C
• Boiling Point: 421.5oC at 760 mmHg
• Flash Point: 194.2oC
• PSA: 50.19000
• Density: 1.309g/cm3
• LogP: 2.06130
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 187.063328530
• Heavy Atom Count: 14
• Complexity: 296

Purity/Quality:

98%min ^*data from raw suppliers

2-Hydroxy-8-methylquinoline-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=CC=C1)C=C(C(=O)N2)C=O

Technology Process of 2-Hydroxy-8-methylquinoline-3-carbaldehyde

There total 5 articles about 2-Hydroxy-8-methylquinoline-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-chloro-8-methyl-quinoline-3-carbaldehyde (73568-26-0) → 8‐methyl‐2‐oxo‐1,2‐dihydroquinoline‐3‐carbaldehyde (101382-54-1)

Guidance literature:

With hydrogenchloride; for 1h; Heating;

Reference yield:

2-chloro-8-methyl-quinoline-3-carbaldehyde (73568-26-0) → 2-hydroxy-8-methyl-quinoline-3-carbaldehyde (101382-54-1)

Guidance literature:

With hydrogenchloride; water; for 1h; Reflux;

DOI:10.1248/cpb.57.557

Reference yield:

N-(2-methylphenyl)acetamide (120-66-1) → 8‐methyl‐2‐oxo‐1,2‐dihydroquinoline‐3‐carbaldehyde (101382-54-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 18 h / 80 °C

2: acetic acid / water / Reflux

With acetic acid; trichlorophosphate; In water;

DOI:10.1016/j.tetlet.2014.05.094

upstream raw materials:

2-chloro-8-methyl-quinoline-3-carbaldehyde

o-toluidine

N-(2-methylphenyl)acetamide

Downstream raw materials:

C₁₇H₁₄N₂O₂

C₁₇H₁₄N₂OS

8-methyl-3-(3-oxo-3-phenylpropenyl)-1H-quinolin-2-one

3-(3-benzoyloxiranyl)-8-methyl-1H-quinolin-2-one