trans-2-methoxycyclohexyl butanoate

Base Information

Chemical Name:trans-2-methoxycyclohexyl butanoate
CAS No.:134070-87-4
Molecular Formula:C₁₁H₂₀O₃
Molecular Weight:200.278
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-2-methoxycyclohexyl butanoate

Chemical Property:

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Technology Process of trans-2-methoxycyclohexyl butanoate

There total 1 articles about trans-2-methoxycyclohexyl butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 106-31-0
butanoic acid anhydride

: 7429-40-5,7429-41-6,113625-71-1,134108-68-2,134108-92-2,2979-24-0
trans-2-methoxycyclohexanol

: 134070-87-4,134108-78-4
trans-2-methoxycyclohexyl butanoate

Guidance literature:: With pyridine; dmap; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1039/p19960002029

Reference yield:

: 134070-87-4,134108-78-4
trans-2-methoxycyclohexyl butanoate

: 134108-92-2
(1S,2S)-2-methoxycyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: 47 percent / phosphate buffer pH=7 / 48 h / Pseudomonas fluorescens lipase

2: 44 percent / aq. NaOH

With sodium hydroxide; phosphate buffer pH=7;
DOI:10.1039/p19960002029

Reference yield:

: 134070-87-4,134108-78-4
trans-2-methoxycyclohexyl butanoate

: {(2R,3S)-2-((1S,3R)-3-Methoxy-2-oxo-cyclohexyl)-3-[(R)-1-(4-nitro-benzyloxycarbonyloxy)-ethyl]-4-oxo-azetidin-1-yl}-oxo-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 13 steps

1: 47 percent / phosphate buffer pH=7 / 48 h / Pseudomonas fluorescens lipase

2: 44 percent / aq. NaOH

3: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH₂Cl₂, -50 to -60 deg C, 15 min, 2.) -50 deg C, 5 min

4: 55 percent / tetrabutylammonium fluoride/ silica / tetrahydrofuran / 1 h / -20 °C

5: ZnCl₂ / CH₂Cl₂ / 18 h / Ambient temperature

6: 86 percent / NaBH₄ / ethanol / 1 h / 0 °C

7: 76 percent / BF₃*Et₂O / CH₂Cl₂ / 5 h / Ambient temperature

8: 1.) LDA, 2.) potassium t-butoxide / 1.) THF, 0 deg C, 30 min, 2.) t-BuOH, -78 to 0 deg C

9: TBAF, acetic acid / tetrahydrofuran / 1 h / Ambient temperature

10: 86 percent / 4-DMAP / CH₂Cl₂ / 12 h / Ambient temperature

11: 90 percent / TFA / H₂O / 1 h / Ambient temperature

12: 1.) oxalyl chloride, DMSO, 2.) triethylamine / 1.) CH₂Cl₂, -50 to -60 deg C, 15 min, 2.) -50 deg C, 5 min

13: triethylamine / CH₂Cl₂ / 1 h / 0 °C

With dmap; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; phosphate buffer pH=7; boron trifluoride diethyl etherate; potassium tert-butylate; tetrabutyl ammonium fluoride; silica gel; acetic acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; zinc(II) chloride; lithium diisopropyl amide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1039/p19960002029