3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2-[(4-hydroxybutoxy)methyl]-6-methyl -, 3-ethyl 5-methyl ester

Base Information

Chemical Name:3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2-[(4-hydroxybutoxy)methyl]-6-methyl -, 3-ethyl 5-methyl ester
CAS No.:101411-59-0
Molecular Formula:C22H27Cl2NO6
Molecular Weight:472.365
Hs Code.:
Mol file:101411-59-0.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2-[(4-hydroxybutoxy)methyl]-6-methyl -, 3-ethyl 5-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2-[(4-hydroxybutoxy)methyl]-6-methyl -, 3-ethyl 5-methyl ester

There total 4 articles about 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2-[(4-hydroxybutoxy)methyl]-6-methyl -, 3-ethyl 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 101411-60-3
methyl 4-<<4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyrid-2-yl>methoxy>-2-butanoate

: 101411-59-0
4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-2-(4-hydroxybutoxy)-methyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 1.16667h;
DOI:10.1016/0223-5234(91)90197-U

Reference yield:

: 101411-65-8
1-<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-propyne

: 101411-59-0
4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-2-(4-hydroxybutoxy)-methyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hHexane, from -70 deg C to -10 deg C, 2.) THF, hexane, -40 deg C, 1 h

2: conc. aq. HCl / 3 h / Heating

3: 40 percent / H₂ / 5percent Pd/CaCO₃ / dioxane / 2 h / Ambient temperature

4: 59 percent / LiAlH₄ / tetrahydrofuran / 1.17 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; n-butyllithium; hydrogen; Lindlar's catalyst; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/0223-5234(91)90197-U

Reference yield:

: 101411-64-7
4<<4-(2,3-dichlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl>methoxy>-2-butynoic acid

: 101411-59-0
4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-2-(4-hydroxybutoxy)-methyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: conc. aq. HCl / 3 h / Heating

2: 40 percent / H₂ / 5percent Pd/CaCO₃ / dioxane / 2 h / Ambient temperature

3: 59 percent / LiAlH₄ / tetrahydrofuran / 1.17 h / 0 °C

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; Lindlar's catalyst; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1016/0223-5234(91)90197-U